Effect of increasing age on the degradation of thyroxine by rat liver homogenate

Steven R. Gambert

Research output: Contribution to journalArticle

Abstract

The effect of increasing age on the ability to metabolize thyroxine by rat liver homogenate was studied. Rats aged 6 weeks (young), 6 months (mature), and 20 months (senescent) showed no difference in the ability to deiodinate thyroxine at the 51-position to form T3. There was, however, an age related decrease in the ability to generate excess iodide, implying less degradation through the 5-monodeiodinase pathway.

Original languageEnglish (US)
Pages (from-to)48-50
Number of pages3
JournalAGE
Volume4
Issue number2
DOIs
StatePublished - Apr 1 1981

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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