Effect of improved fitness beyond weight loss on cardiovascular risk factors in individuals with type 2 diabetes in the Look AHEAD study

Bethany Barone Gibbs, Frederick L. Brancati, Haiying Chen, MacE Coday, John M. Jakicic, Cora E. Lewis, Kerry Stewart, Jeanne Clark

Research output: Contribution to journalArticle

Abstract

Background: Because lifestyle-induced improvements in cardiovascular risk factors vary substantially across individuals with type 2 diabetes, we investigated the extent to which increases in fitness explain cardiovascular risk factor improvements independent of weight loss in a lifestyle intervention. Methods: We studied 1-year changes in Look AHEAD, a randomized trial comparing an intensive lifestyle intervention (ILI) to a diabetes support and education (DSE) control group in adults with type 2 diabetes. Assessments included weight, fitness, blood pressure (BP), glucose, HbA1c, and lipids.We evaluated the effects of changes in weight and fitness on changes in cardiovascular risk factors by study arm, using R2 from multiple linear regression. Results: Analyses included participants with fitness data at baseline and 1-year (n=4408; 41% male, 36% non-white; mean age 58.7 6.8 years). Weight change alone improved R2 for explaining changes in risk factors up to 8.2% in ILI and 1.7% in DSE. Fitness change alone improved R2 up to 3.9% in ILI and 0.8% in DSE. After adjusting for weight change, fitness was independently associated (p

Original languageEnglish (US)
Pages (from-to)608-617
Number of pages10
JournalEuropean Journal of Preventive Cardiology
Volume21
Issue number5
DOIs
StatePublished - 2014

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Type 2 Diabetes Mellitus
Life Style
Weight Loss
Weights and Measures
Education
Blood Glucose
Linear Models
Blood Pressure
Lipids
Control Groups

Keywords

  • Cardiovascular risk factor
  • fitness
  • lifestyle intervention
  • obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Epidemiology
  • Medicine(all)

Cite this

Effect of improved fitness beyond weight loss on cardiovascular risk factors in individuals with type 2 diabetes in the Look AHEAD study. / Gibbs, Bethany Barone; Brancati, Frederick L.; Chen, Haiying; Coday, MacE; Jakicic, John M.; Lewis, Cora E.; Stewart, Kerry; Clark, Jeanne.

In: European Journal of Preventive Cardiology, Vol. 21, No. 5, 2014, p. 608-617.

Research output: Contribution to journalArticle

Gibbs, Bethany Barone ; Brancati, Frederick L. ; Chen, Haiying ; Coday, MacE ; Jakicic, John M. ; Lewis, Cora E. ; Stewart, Kerry ; Clark, Jeanne. / Effect of improved fitness beyond weight loss on cardiovascular risk factors in individuals with type 2 diabetes in the Look AHEAD study. In: European Journal of Preventive Cardiology. 2014 ; Vol. 21, No. 5. pp. 608-617.
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