Effect of hypoxia on laryngeal reflex apnea - implications for sudden infant death

B. Lanier, M. A. Richardson, Charles W Cummings

Research output: Contribution to journalArticle

Abstract

Apnea was elicited by the application of chemical stimuli to the laryngeal region of 25 piglets from 1 to 70 days of age. Animals were tested under normoxic and hypoxic (Fl(O2) 10%) conditions with water and solutions of graded acid and salt concentration. The chemoreflex was found to diminish with postnatal age. Fatal apneic episodes were confined to animals less than 3 weeks of age. Hypoxia consistently augmented the reflex, and in some cases elicited fatal apnea in animals that had survived similar stimulation under normoxic conditions. A direct relationship was also found between the strength of stimulus and respiratory response. Apnea increased with diminishing NaCl concentration or pH. The reflex was abolished by bilateral section of the superior laryngeal nerves. Fatal apnea elicited by laryngeal chemostimulation under the circumstance of hypoxia may provide further insight into the enigma of sudden infant death.

Original languageEnglish (US)
Pages (from-to)597-604
Number of pages8
JournalOtolaryngology - Head and Neck Surgery
Volume91
Issue number6
StatePublished - 1983
Externally publishedYes

Fingerprint

Sudden Infant Death
Apnea
Reflex
Laryngeal Nerves
Salts
Acids
Hypoxia
Water

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Effect of hypoxia on laryngeal reflex apnea - implications for sudden infant death. / Lanier, B.; Richardson, M. A.; Cummings, Charles W.

In: Otolaryngology - Head and Neck Surgery, Vol. 91, No. 6, 1983, p. 597-604.

Research output: Contribution to journalArticle

@article{b32f9425b34c4e8ca6ab24dcbf4d4d15,
title = "Effect of hypoxia on laryngeal reflex apnea - implications for sudden infant death",
abstract = "Apnea was elicited by the application of chemical stimuli to the laryngeal region of 25 piglets from 1 to 70 days of age. Animals were tested under normoxic and hypoxic (Fl(O2) 10{\%}) conditions with water and solutions of graded acid and salt concentration. The chemoreflex was found to diminish with postnatal age. Fatal apneic episodes were confined to animals less than 3 weeks of age. Hypoxia consistently augmented the reflex, and in some cases elicited fatal apnea in animals that had survived similar stimulation under normoxic conditions. A direct relationship was also found between the strength of stimulus and respiratory response. Apnea increased with diminishing NaCl concentration or pH. The reflex was abolished by bilateral section of the superior laryngeal nerves. Fatal apnea elicited by laryngeal chemostimulation under the circumstance of hypoxia may provide further insight into the enigma of sudden infant death.",
author = "B. Lanier and Richardson, {M. A.} and Cummings, {Charles W}",
year = "1983",
language = "English (US)",
volume = "91",
pages = "597--604",
journal = "Otolaryngology - Head and Neck Surgery",
issn = "0194-5998",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Effect of hypoxia on laryngeal reflex apnea - implications for sudden infant death

AU - Lanier, B.

AU - Richardson, M. A.

AU - Cummings, Charles W

PY - 1983

Y1 - 1983

N2 - Apnea was elicited by the application of chemical stimuli to the laryngeal region of 25 piglets from 1 to 70 days of age. Animals were tested under normoxic and hypoxic (Fl(O2) 10%) conditions with water and solutions of graded acid and salt concentration. The chemoreflex was found to diminish with postnatal age. Fatal apneic episodes were confined to animals less than 3 weeks of age. Hypoxia consistently augmented the reflex, and in some cases elicited fatal apnea in animals that had survived similar stimulation under normoxic conditions. A direct relationship was also found between the strength of stimulus and respiratory response. Apnea increased with diminishing NaCl concentration or pH. The reflex was abolished by bilateral section of the superior laryngeal nerves. Fatal apnea elicited by laryngeal chemostimulation under the circumstance of hypoxia may provide further insight into the enigma of sudden infant death.

AB - Apnea was elicited by the application of chemical stimuli to the laryngeal region of 25 piglets from 1 to 70 days of age. Animals were tested under normoxic and hypoxic (Fl(O2) 10%) conditions with water and solutions of graded acid and salt concentration. The chemoreflex was found to diminish with postnatal age. Fatal apneic episodes were confined to animals less than 3 weeks of age. Hypoxia consistently augmented the reflex, and in some cases elicited fatal apnea in animals that had survived similar stimulation under normoxic conditions. A direct relationship was also found between the strength of stimulus and respiratory response. Apnea increased with diminishing NaCl concentration or pH. The reflex was abolished by bilateral section of the superior laryngeal nerves. Fatal apnea elicited by laryngeal chemostimulation under the circumstance of hypoxia may provide further insight into the enigma of sudden infant death.

UR - http://www.scopus.com/inward/record.url?scp=0021053433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021053433&partnerID=8YFLogxK

M3 - Article

C2 - 6420739

AN - SCOPUS:0021053433

VL - 91

SP - 597

EP - 604

JO - Otolaryngology - Head and Neck Surgery

JF - Otolaryngology - Head and Neck Surgery

SN - 0194-5998

IS - 6

ER -