Effect of hypoxia on carotid chemoreceptor response to carbon dioxide in cats

Robert S. Fitzgerald, Dorothy C. Parks

Research output: Contribution to journalArticlepeer-review

132 Scopus citations


Carotid nerve C2 response curves were measured in 5 cats. Carotid nerve activity (per cent of a maximum response to asphyxia) was recorded for several values of Paco2 at different levels ofPao2. At higher Pao2 values the activity was less for a given Paco2, though there was a considerable response to increases in Paco2 even when Pao2, was 450 mm Hg. At lower Pao2 values the CO2 response curve tended to flatten out as Paco2 increased. However, by lowering the Pao2 at a given Paco2 an increase in carotid activity could be observed. The data suggest that under conditions of hypoxia two different receptor systems in the carotid body may be stimulated or the same system in two different ways; that the hypoxia-produced transmitter in the carotid body is not essentially dependent on an increased (H+a).

Original languageEnglish (US)
Pages (from-to)218-229
Number of pages12
JournalRespiration Physiology
Issue number2
StatePublished - Jun 1971
Externally publishedYes


  • Arterial chemoreceptors
  • Carotid body
  • Control of breathing
  • Hypercapnia
  • Hypoxia
  • Respiratory stimuli

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Effect of hypoxia on carotid chemoreceptor response to carbon dioxide in cats'. Together they form a unique fingerprint.

Cite this