Effect of hypercapnic acidosis on induction of arrhythmias by catecholamines in cat papillary muscles

Elba S. De Castuma, Alicia R. Mattiazzi, H. E. Cingolani

Research output: Contribution to journalArticle

Abstract

The effect of changes in Pco2 upon induction of arrhythmias in cat papillary muscles was studied. The average norepinephrine (NE) dose necessary to produce spontaneous contractions in muscles stimulated at rates of 10/min was higher at high Pco2. Whereas 2 100 ± 295 ± 10-8 mol/litre of NE was necessary during acidosis, only 824 ± 295 ± 10-8 mol/litre was necessary to produce spontaneous contractions in alkalosis. In quiescent muscles, the necessary doses in acidosis and alkalosis were 2 209 ± 531 ± 10-8 and 518 ± 159 ± 10-8 mol/litre respectively. With isoproterenol 458 ±: 84 ± 10-8 mol/litre was necessary to reach the end point at high Pco2, whereas only 131 ± 52 × 10-8 mol/litre was required at low Pco2. The lower sensitivity to catechola-mine-induced arrhythmias with hypercapnic acidosis does not appear to be related to the re-uptake of the neurotransmitter by the nerve ending since it is also present with isoproterenol.

Original languageEnglish (US)
Pages (from-to)509-518
Number of pages10
JournalArchives of Physiology and Biochemistry
Volume85
Issue number3
DOIs
StatePublished - 1977
Externally publishedYes

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Papillary Muscles
Acidosis
Catecholamines
Muscle
Cardiac Arrhythmias
Alkalosis
Cats
Isoproterenol
Norepinephrine
Nerve Endings
Muscle Contraction
Neurotransmitter Agents
Muscles

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Biochemistry

Cite this

Effect of hypercapnic acidosis on induction of arrhythmias by catecholamines in cat papillary muscles. / De Castuma, Elba S.; Mattiazzi, Alicia R.; Cingolani, H. E.

In: Archives of Physiology and Biochemistry, Vol. 85, No. 3, 1977, p. 509-518.

Research output: Contribution to journalArticle

De Castuma, Elba S. ; Mattiazzi, Alicia R. ; Cingolani, H. E. / Effect of hypercapnic acidosis on induction of arrhythmias by catecholamines in cat papillary muscles. In: Archives of Physiology and Biochemistry. 1977 ; Vol. 85, No. 3. pp. 509-518.
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