Effect of human immunodeficiency virus type 1 infection on the antibody response to a glycoprotein conjugate pneumococcal vaccine: Results from a randomized trial

Faruque Ahmed, Mark C. Steinhoff, Maria C. Rodriguez-Barradas, Robert G. Hamilton, Daniel M. Musher, Kenrad E. Nelson

Research output: Contribution to journalArticlepeer-review

Abstract

Adults (n = 282) were randomized to receive either a pneumococcal glycoprotein conjugate vaccine, composed of pneumococcal serotypes 6B, 14, 18C, 19F, and 23F linked to CRM197, or a 23-valent pneumococcal polysaccharide vaccine. Among human immunodeficiency virus (HIV)uninfected persons, conjugate vaccine elicited significantly higher IgG antibody geometric mean liters (GMTs) than did polysaccharide vaccine for serotypes 6B, 18C, and 23F: IgG GMTs were 9.0 versus 4.8, 23.2 versus 5.9, and 15.3 versus 4.4 μg/mL, respectively. In contrast, the two vaccines elicited similar antibody GMTs in HIV-infected persons: GMTs ranged from 1.3 to 10.8 μg/mL for all serotypes. Of note, among persons receiving polysaccharide vaccine, antibody GMTs in HIV-uninfected and -infected persons with CD4 lymphocytes ≥500/μL were similar. These data underscore the importance of controlled clinical evaluations of newer pneumococcal vaccines in all high- risk groups for whom pneumococcal immunization is recommended and highlight the need for early immunization of HIV-infected persons with currently available polysaccharide vaccines.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalJournal of Infectious Diseases
Volume173
Issue number1
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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