Effect of human immunodeficiency virus infection on the prevalence and incidence of vaginal intraepithelial neoplasia

L. Stewart Massad, Xianhong Xie, Ruth M. Greenblatt, Howard Minkoff, Lorraine Sanchez-Keeland, D. Heather Watts, Rodney L. Wright, Gypsyamber D'Souza, Daniel Merenstein, Howard Strickler

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To estimate the prevalence, incidence, and clearance of abnormal vaginal cytology and vaginal intraepithelial neoplasia (VAIN) in human immunodeficiency virus (HIV)-seropositive women. METHODS: Pap tests were done semiannually for 335 HIV-seropositive and 75 HIV-seronegative women with prior hysterectomy in the prospective Women's Interagency HIV Study cohort. End points included abnormal Pap test results after hysterectomy and VAIN regardless of hysterectomy. RESULTS: Over a median of 5.6 years of follow-up, vaginal Pap test results were abnormal at 1,076 (29%; 95% confidence interval [CI] 25-33%) of 3,700 visits among HIV-seropositive compared with 31 (4%; 95% CI 2-8%) of 763 visits among HIV-seronegative women (P

Original languageEnglish (US)
Pages (from-to)582-589
Number of pages8
JournalObstetrics and Gynecology
Volume119
Issue number3
DOIs
StatePublished - Mar 2012

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Virus Diseases
HIV
Papanicolaou Test
Incidence
Neoplasms
Hysterectomy
Confidence Intervals
Vaginal Hysterectomy
Cell Biology
Cohort Studies

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Massad, L. S., Xie, X., Greenblatt, R. M., Minkoff, H., Sanchez-Keeland, L., Watts, D. H., ... Strickler, H. (2012). Effect of human immunodeficiency virus infection on the prevalence and incidence of vaginal intraepithelial neoplasia. Obstetrics and Gynecology, 119(3), 582-589. https://doi.org/10.1097/AOG.0b013e318244ee3d

Effect of human immunodeficiency virus infection on the prevalence and incidence of vaginal intraepithelial neoplasia. / Massad, L. Stewart; Xie, Xianhong; Greenblatt, Ruth M.; Minkoff, Howard; Sanchez-Keeland, Lorraine; Watts, D. Heather; Wright, Rodney L.; D'Souza, Gypsyamber; Merenstein, Daniel; Strickler, Howard.

In: Obstetrics and Gynecology, Vol. 119, No. 3, 03.2012, p. 582-589.

Research output: Contribution to journalArticle

Massad, LS, Xie, X, Greenblatt, RM, Minkoff, H, Sanchez-Keeland, L, Watts, DH, Wright, RL, D'Souza, G, Merenstein, D & Strickler, H 2012, 'Effect of human immunodeficiency virus infection on the prevalence and incidence of vaginal intraepithelial neoplasia', Obstetrics and Gynecology, vol. 119, no. 3, pp. 582-589. https://doi.org/10.1097/AOG.0b013e318244ee3d
Massad, L. Stewart ; Xie, Xianhong ; Greenblatt, Ruth M. ; Minkoff, Howard ; Sanchez-Keeland, Lorraine ; Watts, D. Heather ; Wright, Rodney L. ; D'Souza, Gypsyamber ; Merenstein, Daniel ; Strickler, Howard. / Effect of human immunodeficiency virus infection on the prevalence and incidence of vaginal intraepithelial neoplasia. In: Obstetrics and Gynecology. 2012 ; Vol. 119, No. 3. pp. 582-589.
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