Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDS

Efe Sezgin, Sher L. Hendrickson, Douglas A. Jabs, Mark L. Van Natta, Richard A. Lewis, Jennifer L. Troyer, Stephen J. O'Brien

Research output: Contribution to journalArticlepeer-review

Abstract

Approximately 10%-15% of patients with AIDS but without ocular opportunistic infections will have a presumed neuroretinal disorder (HIV-NRD), manifested by reduced contrast sensitivity and abnormal visual fields. The loss of contrast sensitivity often is sufficient to impair reading speed. To evaluate the effect of host genetics on HIV-NRD, we explored validated AIDS restriction gene variants CCR5Δ32, CCR2-64I, CCR5 P1, SDF-3'A, IL-10-5'A, RANTES-403A, RANTES-28G, RANTES-In1.1C, CX3CR1-249I, CX3CR1-280M, IFNG-179T, MDR1-3435T, and MCP-1364G, each of which has been implicated previously to influence HIV-1 infection, AIDS progression, therapy response, and antiviral drug metabolism, and an IL-10 receptor gene, IL-10R1, in the Longitudinal Study of the Ocular Complications of AIDS cohort. In European Americans (cases = 55, controls = 290), IL-10-5'A variant and its promoter haplotype (hazard ratio = 2.09, confidence interval. 1.19 to 3.67, P = 0.01), in African Americans (cases = 54, controls = 180), RANTES-In1.1C and the associated haplotype (hazard ratio = 2.72, confidence interval.: 1.48 to 5.00, P = 0.001), showed increased HIV-NRD susceptibility. Although sample sizes are small and P values do not pass a strict Bonferroni correction, our results suggest that, in European Americans, an IL-10-related pathway, and, in African Americans, chemokine receptor ligand polymorphisms in RANTES are risk factors for HIV-NRD development. Clearly, further studies are warrented.

Original languageEnglish (US)
Pages (from-to)343-351
Number of pages9
JournalJournal of acquired immune deficiency syndromes
Volume54
Issue number4
DOIs
StatePublished - Aug 1 2010

Keywords

  • AIDS
  • HIV-1
  • HIV-neuroretinal disorder
  • host genetics

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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