Effect of HIV-infection and cumulative viral load on age-related decline in grip strength

for the Multicenter AIDS Cohort Study

Research output: Contribution to journalArticle

Abstract

OBJECTIVE:: Grip strength predicts functional decline and death, and is regarded as a biomarker of biological aging. The primary objective of this manuscript was to assess differences in the rate of decline in grip strength in persons aging with and without HIV. DESIGN:: Grip strength was assessed in 1,552 (716 HIV+ and 836 HIV-) men ≥ 50 years participating in the Multicenter AIDS Cohort Study between 2007 and 2014. METHODS:: Grip strength decline was modeled longitudinally, adjusting for serostatus, demographics, comorbidities, and conditions. In HIV-specificmodels, coefficients were included for cumulative viral load and history of AIDS. RESULTS:: Grip strength at age 50 averaged 37.9?kg and 38.2?kg for HIV+ and HIV- men, respectively (p?=?0.70). In fully adjusted models, grip strength declined 0.33?kg/yr in HIV- men (p?<?0.001) and 0.42?kg/yr in HIV+ men (p?=?0.01). In HIV-stratified models, higher cumulative viral load indicated greater strength decline (-0.884?kg for 3.1 – 4.0 log10?copies-years/mL and -1.077?kg for ≥ 4.1 log10?copies-years/mL) relative to men with consistently low viral load (≤ 3.0 log10?copies-years/mL). Adjusted Cox proportional hazard models revealed a 70% greater risk of clinically weak grip strength in HIV+ men (aHR 1.70; 95% CI, 1.22 – 2.40). CONCLUSIONS:: Grip strength decline is accelerated in HIV-infected men, which may contribute to decreased life expectancy and lower quality of life with aging. Greater cumulative viral load exposure appears to be an important driver of this decline and underscores the importance of early initiation of therapy.

Original languageEnglish (US)
JournalAIDS
DOIs
StateAccepted/In press - Sep 6 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Medicine(all)
  • Infectious Diseases

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