Effect of high-frequency ventilation on histamine-induced lung injury in dogs

G. G. Weinmann, W. Mitzner

Research output: Contribution to journalArticlepeer-review


We compared the effects of high-frequency oscillation (HFO) and conventional mechanical ventilation (CMV) on dynamic lung compliance (C(dyn)), venous admixture (Q̇sp/Q̇t), cardiac output and total lung resistance (R(L)) in seven mongrel dogs with histamine-induced lung injury. Baseline measurements during CMV were followed by iv infusion of histamine at 100 μg/min. C(dyn), Q̇sp/Q̇t, cardiac output, and R(L) were measured in triplicate during CMV and then during HFO. Subsequently, at least one complete set of measurements was recorded again on CMV. During HFO, animals were ventilated at 15 Hz with a tidal volume of 70 to 80 ml. CMV was delivered at 15 to 18 breath/min with a tidal volume of 15 ml/kg. Histamine infusion produced a marked fall in C(dyn), a variable rise in R(L), an inconsistent but usually progressive rise in Q̇sp/Q̇t, and hypotension. A period of ventilation with HFO made no difference in the C(dyn), Q̇sp/Q̇t, or cardiac output changes produced by histamine infusion.

Original languageEnglish (US)
Pages (from-to)571-575
Number of pages5
JournalCritical care medicine
Issue number7
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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