Effect of 'high-dose' amikacin in children

K. M. Kumor, J. M. McDonald, P. S. Lietman

Research output: Contribution to journalArticlepeer-review


17 children with serious infections were treated for an average period of 9.5 days with 420 mg/m2/dose of amikacin every 8 hr. The nephrotoxicity and ototoxicity of this 'high-dose' regimen was studied. None of the children had evidence of nephrotoxicity. Of 9 children who could be clearly evaluated, 1 child experienced a delayed transient auditory dysfunction. 1 child experienced delayed serious deafness, but was receiving other ototoxic drugs. Despite the fact that the doses averaged 54.1 mg/kg/day, 5 children in our series had peak concentrations lower than that recommended for adults with serious infection.

Original languageEnglish (US)
Pages (from-to)368-376
Number of pages9
JournalDevelopmental Pharmacology and Therapeutics
Issue number6
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)


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