TY - JOUR
T1 - Effect of hexavalent chromium on testicular maturation in the rat
AU - Saxena, Daya K.
AU - Murthy, Ramesh C.
AU - Lal, Bachchu
AU - Srivastava, Ratan S.
AU - Chandra, Satya V.
PY - 1990
Y1 - 1990
N2 - Daily intraperitoneal administration of hexavalent chromium (Cr6+; 1, 2, and 3 mg/kg intraperitoneally as potassium dichromate) in weaned rats for an entire duration of 55 and 90 days of age produced dose- and duration-dependent enzymatic and pathologic alterations. At 55 days, the pathologic changes were not seen in testes of Cr6+ treated rats, but the activities of sorbitol dehydrogenase, lactic dehydrogenase, λ-glutamyl transpeptidase, and glucose-6-phosphate dehydrogenase were significantly altered. When the treatment was prolonged to sexual maturity, that is, 90 days of age, the alterations in enzyme activities were greater, and there were dose-dependent pathologic changes in the testes of Cr6+-treated rats. These alterations suggest a risk to growing testes if rats are exposed to Cr6+ during the prepubertal stage of development, which, in turn, may disturb normal testicular physiology at adulthood.
AB - Daily intraperitoneal administration of hexavalent chromium (Cr6+; 1, 2, and 3 mg/kg intraperitoneally as potassium dichromate) in weaned rats for an entire duration of 55 and 90 days of age produced dose- and duration-dependent enzymatic and pathologic alterations. At 55 days, the pathologic changes were not seen in testes of Cr6+ treated rats, but the activities of sorbitol dehydrogenase, lactic dehydrogenase, λ-glutamyl transpeptidase, and glucose-6-phosphate dehydrogenase were significantly altered. When the treatment was prolonged to sexual maturity, that is, 90 days of age, the alterations in enzyme activities were greater, and there were dose-dependent pathologic changes in the testes of Cr6+-treated rats. These alterations suggest a risk to growing testes if rats are exposed to Cr6+ during the prepubertal stage of development, which, in turn, may disturb normal testicular physiology at adulthood.
KW - potassium dichromate
KW - rat
KW - testicular maturation
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U2 - 10.1016/0890-6238(90)90062-Z
DO - 10.1016/0890-6238(90)90062-Z
M3 - Article
C2 - 2136040
AN - SCOPUS:0025528458
SN - 0890-6238
VL - 4
SP - 223
EP - 228
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 3
ER -