Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication

Laura F. Mcnicholas, Amber M. Holbrook, Kevin E. O'Grady, Hendrée E. Jones, Mara G. Coyle, Peter R. Martin, Sarah H. Heil, Susan M. Stine, Karol Kaltenbach

Research output: Contribution to journalArticle

Abstract

Aim: To examine hepatic enzyme test results throughout the course of pregnancy in women maintained on methadone or buprenorphine. Design: Participants were randomized to either methadone or buprenorphine maintenance. Blood chemistry tests, including liver transaminases and hepatitis C virus (HCV) status, were determined every 4 weeks and once postpartum. As part of a planned secondary analysis, generalized mixed linear models were conducted with aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) as the dependent variables. Setting: Six US sites and one European site that provided comprehensive treatment to pregnant opioid-dependent women. Participants: A total of 175 opioid-dependent pregnant women enrolled in the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study. Findings: ALT, AST and GGT levels decreased for all subjects across pregnancy trimesters, rising slightly postpartum. HCV-positive subjects exhibited higher transaminases at all time-points compared to HCV-negative subjects, regardless of medication (all Ps

Original languageEnglish (US)
Pages (from-to)91-97
Number of pages7
JournalAddiction
Volume107
Issue numberSUPPL.1
DOIs
StatePublished - Nov 2012

Fingerprint

Hepacivirus
Opioid Analgesics
Pregnant Women
Buprenorphine
Methadone
Transferases
Aspartate Aminotransferases
Alanine Transaminase
Postpartum Period
Liver
Enzymes
Pregnancy Trimesters
Hematologic Tests
Transaminases
Linear Models
Mothers
Pregnancy
Therapeutics
Research
valine-pyruvate transaminase

Keywords

  • Buprenorphine
  • Liver transaminases
  • Methadone
  • Opioids
  • Pregnancy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Mcnicholas, L. F., Holbrook, A. M., O'Grady, K. E., Jones, H. E., Coyle, M. G., Martin, P. R., ... Kaltenbach, K. (2012). Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication. Addiction, 107(SUPPL.1), 91-97. https://doi.org/10.1111/j.1360-0443.2012.04043.x

Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication. / Mcnicholas, Laura F.; Holbrook, Amber M.; O'Grady, Kevin E.; Jones, Hendrée E.; Coyle, Mara G.; Martin, Peter R.; Heil, Sarah H.; Stine, Susan M.; Kaltenbach, Karol.

In: Addiction, Vol. 107, No. SUPPL.1, 11.2012, p. 91-97.

Research output: Contribution to journalArticle

Mcnicholas, LF, Holbrook, AM, O'Grady, KE, Jones, HE, Coyle, MG, Martin, PR, Heil, SH, Stine, SM & Kaltenbach, K 2012, 'Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication', Addiction, vol. 107, no. SUPPL.1, pp. 91-97. https://doi.org/10.1111/j.1360-0443.2012.04043.x
Mcnicholas, Laura F. ; Holbrook, Amber M. ; O'Grady, Kevin E. ; Jones, Hendrée E. ; Coyle, Mara G. ; Martin, Peter R. ; Heil, Sarah H. ; Stine, Susan M. ; Kaltenbach, Karol. / Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication. In: Addiction. 2012 ; Vol. 107, No. SUPPL.1. pp. 91-97.
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