Effect of HAART on incident cancer and noncancer AIDS events among male HIV seroconverters

Meredith S. Shiels, Stephen R. Cole, Scott Wegner, Haroutune Armenian, Joan S. Chmiel, Anuradha Anesan, Vincent C. Marconi, Otoniel Martinez-Maza, Jeremy Martinson, Amy Weintrob, Lisa P. Jacobson, Nancy F. Crum-Cianflone

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE:: To explore the impact of highly active antiretroviral therapy (HAART) on the prevention of AIDS-defining cancers relative to other AIDS-defining events. DESIGN:: Prospective cohort study using 2121 HIV+ male seroconverters (median age: 28 years, 51% white/non-Hispanic) in the Tri-Service AIDS Clinical Consortium (n = 1694) and the Multicenter AIDS Cohort Study (n = 427). METHODS:: Poisson regression models, with calendar periods to represent antiretroviral therapy, were extended to analyze first incident AIDS-defining cancers and other first AIDS-defining events as competing risks. RESULTS:: Eighty-one AIDS-defining cancers (64 Kaposi sarcomas; 17 non-Hodgkin lymphomas) and 343 other AIDS events occurred during 14,483 person-years in 1990-2006. The rate ratio of AIDS-defining cancers during the HAART calendar period was 0.26 (95% confidence limits: 0.15, 0.46) and of other AIDS-defining events was 0.28 (95% confidence limits: 0.21, 0.36) compared with the monotherapy/combination therapy calendar period, adjusting for age, infection duration, race, and cohort. The association of HAART with decreased AIDS incidence seemed to be equal (interaction ratio = 0.95 (95% confidence limits: 0.51, 1.74) for AIDS-defining cancers and other AIDS-defining events. CONCLUSIONS:: In human immunodeficiency virus-infected men, HAART seems equally protective against first AIDS-defining cancers and other first AIDS-defining events.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalJournal of acquired immune deficiency syndromes
Volume48
Issue number4
DOIs
StatePublished - Aug 1 2008

Keywords

  • AIDS-associated lymphoma
  • Cancers
  • Epidemiology
  • Highly active antiretroviral therapy
  • Kaposi sarcoma
  • Opportunistic nfections

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Effect of HAART on incident cancer and noncancer AIDS events among male HIV seroconverters'. Together they form a unique fingerprint.

Cite this