Effect of glucagon-like peptide-1 (7-37) on beta-cell function after islet transplantation in type 1 diabetes

Michelle Fung, David Thompson, R. Jean Shapiro, Garth L. Warnock, Dana K. Andersen, Dariush Elahi, Graydon S. Meneilly

Research output: Contribution to journalArticle

Abstract

Islet transplantation can improve glycemic control in patients with type 1 diabetes and reduce or eliminate the need for insulin. Glucagon-like peptide-1 (GLP-1) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion, and has a trophic effect on beta-cells. We evaluated the effect of GLP-1 on insulin secretion after islet transplantation. Patients underwent hyperglycemic glucose clamp studies 1 month after their last transplant. GLP-1 was infused during the second hour of the hyperglycemic clamp. Results were compared to normal control subjects and patients with type 2 diabetes who underwent an identical hyperglycemic clamp. First phase insulin release was absent in patients, while second phase insulin was not significantly reduced (control: 118 ± 29 pM; type 2 diabetes: 68 ± 20 pM; transplant: 99 ± 18 pM, p = ns for all). GLP-1 had a significant incretin effect on transplanted islets but the response was less than controls (control: 2108 ± 344 pM; type 2 diabetes: 929 ± 331 pM; transplant: 329 ± 112 pM, p < 0.0001 control versus transplant). Islet transplant patients had no evidence of resistance to insulin mediated glucose disposal. We conclude that transplanted islets retain the ability to respond to GLP-1.

Original languageEnglish (US)
Pages (from-to)189-193
Number of pages5
JournalDiabetes Research and Clinical Practice
Volume74
Issue number2
DOIs
StatePublished - Nov 1 2006

Keywords

  • GLP-1
  • Incretin
  • Islet transplantation
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Fung, M., Thompson, D., Shapiro, R. J., Warnock, G. L., Andersen, D. K., Elahi, D., & Meneilly, G. S. (2006). Effect of glucagon-like peptide-1 (7-37) on beta-cell function after islet transplantation in type 1 diabetes. Diabetes Research and Clinical Practice, 74(2), 189-193. https://doi.org/10.1016/j.diabres.2006.03.022