Effect of formalin fixation on the activity of five enzymes of rat liver

Arnold M. Seligman, Howard H. Chauncey, Marvin M. Nachlas

Research output: Contribution to journalArticle

Abstract

The effect of formalin fixation on the enzymatic activity of five enzymes in rat liver was studied as a function of time and temperature, βglucuronidase was found to be most resistant to the inactivating effects of formalin. At a time when fixation was satisfactory for preparing frozen sections (24 hours), considerable enzymatic activity was present in decreasing order; βglucuronidase, sulfatase, acid phosphatase, esterase, and alkaline phosphatase.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalBiotechnic and Histochemistry
Volume26
Issue number1
DOIs
StatePublished - Jan 1 1951

ASJC Scopus subject areas

  • Histology
  • Medical Laboratory Technology

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