Effect of food and acid-reducing agents on the absorption of oral targeted therapies in solid tumors

Annelieke E C A B Willemsen, Floor J E Lubberman, Jolien Tol, Winald R. Gerritsen, Carla M L van Herpen, Nielka P. van Erp

Research output: Contribution to journalArticle

Abstract

Oral targeted therapies represent an increasingly important group of drugs within modern oncology. With the shift from intravenously to orally administered drugs, drug absorption is a newly introduced factor in drug disposition. The process of absorption can have a large effect on inter- and intrasubject variability in drug exposure and thereby potentially treatment benefit or the severity of toxicities.The intake of oral targeted therapies with food and concomitant use of acid-reducing agents (ARAs) can significantly affect drug absorption. The size and direction of the effect of food and ARAs on drug absorption varies among drugs as a result of different chemical characteristics. Therefore, an awareness and understanding of these effects for each drug is essential to optimize patient outcomes. Intake of oral targeted anticancer agents with food or acid-reducing agents can majorly affect drug absorption and thereby potentially treatment benefit or the severity of toxicities.

Original languageEnglish (US)
JournalDrug Discovery Today
DOIs
StateAccepted/In press - 2016
Externally publishedYes

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Reducing Agents
Food
Acids
Pharmaceutical Preparations
Neoplasms
Therapeutics
Essential Drugs
Antineoplastic Agents

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Willemsen, A. E. C. A. B., Lubberman, F. J. E., Tol, J., Gerritsen, W. R., van Herpen, C. M. L., & van Erp, N. P. (Accepted/In press). Effect of food and acid-reducing agents on the absorption of oral targeted therapies in solid tumors. Drug Discovery Today. https://doi.org/10.1016/j.drudis.2016.03.002

Effect of food and acid-reducing agents on the absorption of oral targeted therapies in solid tumors. / Willemsen, Annelieke E C A B; Lubberman, Floor J E; Tol, Jolien; Gerritsen, Winald R.; van Herpen, Carla M L; van Erp, Nielka P.

In: Drug Discovery Today, 2016.

Research output: Contribution to journalArticle

Willemsen, Annelieke E C A B ; Lubberman, Floor J E ; Tol, Jolien ; Gerritsen, Winald R. ; van Herpen, Carla M L ; van Erp, Nielka P. / Effect of food and acid-reducing agents on the absorption of oral targeted therapies in solid tumors. In: Drug Discovery Today. 2016.
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