TY - JOUR
T1 - Effect of food and acid-reducing agents on the absorption of oral targeted therapies in solid tumors
AU - Willemsen, Annelieke E.C.A.B.
AU - Lubberman, Floor J.E.
AU - Tol, Jolien
AU - Gerritsen, Winald R.
AU - Van Herpen, Carla M.L.
AU - Van Erp, Nielka P.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd. All rights reserved.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Oral targeted therapies represent an increasingly important group of drugs within modern oncology. With the shift from intravenously to orally administered drugs, drug absorption is a newly introduced factor in drug disposition. The process of absorption can have a large effect on inter- and intrasubject variability in drug exposure and thereby potentially treatment benefit or the severity of toxicities. The intake of oral targeted therapies with food and concomitant use of acid-reducing agents (ARAs) can significantly affect drug absorption. The size and direction of the effect of food and ARAs on drug absorption varies among drugs as a result of different chemical characteristics. Therefore, an awareness and understanding of these effects for each drug is essential to optimize patient outcomes.
AB - Oral targeted therapies represent an increasingly important group of drugs within modern oncology. With the shift from intravenously to orally administered drugs, drug absorption is a newly introduced factor in drug disposition. The process of absorption can have a large effect on inter- and intrasubject variability in drug exposure and thereby potentially treatment benefit or the severity of toxicities. The intake of oral targeted therapies with food and concomitant use of acid-reducing agents (ARAs) can significantly affect drug absorption. The size and direction of the effect of food and ARAs on drug absorption varies among drugs as a result of different chemical characteristics. Therefore, an awareness and understanding of these effects for each drug is essential to optimize patient outcomes.
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U2 - 10.1016/j.drudis.2016.03.002
DO - 10.1016/j.drudis.2016.03.002
M3 - Review article
C2 - 26995271
AN - SCOPUS:84961960803
SN - 1359-6446
VL - 21
SP - 962
EP - 976
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 6
ER -