Effect of folic acid supplementation on risk of new-onset diabetes in adults with hypertension in China

Findings from the China Stroke Primary Prevention Trial (CSPPT)

Xianhui Qin, Jianping Li, Yan Zhang, Dafang Chen, Binyan Wang, Mingli He, Jia Fu, Genfu Tang, Yefeng Cai, Xiuli Shi, Xin Xu, Fan Fan Hou, Xiaobin Wang, Yong Huo

Research output: Contribution to journalArticle

Abstract

Background: The aim of the present post hoc analysis of the China Stroke Primary Prevention Trial (CSPPT) was to evaluate the effect of folic acid supplementation on the risk of new-onset diabetes in hypertensive adults in China. Methods: In all, 20 702 hypertensive adults with no history of stroke and/or myocardial infarction (MI) were randomly assigned to receive double-blind daily treatment with tablets containing either: (i) 10 mg enalapril and 0.8 mg folic acid (n = 10 348); or (ii) 10 mg enalapril alone (n = 10 354). New-onset diabetes was defined as either self-reported physician-diagnosed diabetes or the use of glucose-lowering drugs during the follow-up period of the CSPPT. Results: Over a median treatment duration of 4.5 years, new-onset diabetes occurred in 198 (2.0%) and 214 (2.1%) subjects in the enalapril-folic acid and enalapril groups, respectively (hazard ratio [HR] 0.92; 95% confidence interval [CI] 0.76-1.12). Similar results were observed when analyses were limited to subjects with baseline fasting glucose (FG)

Original languageEnglish (US)
Pages (from-to)286-294
Number of pages9
JournalJournal of Diabetes
Volume8
Issue number2
DOIs
StatePublished - Mar 1 2016

Fingerprint

Enalapril
Primary Prevention
Folic Acid
China
Stroke
Hypertension
Glucose
Tablets
Fasting
Myocardial Infarction
Confidence Intervals
Physicians
Therapeutics
Pharmaceutical Preparations

Keywords

  • Folic acid supplementation
  • Hypertensive Chinese adults
  • New-onset diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Effect of folic acid supplementation on risk of new-onset diabetes in adults with hypertension in China : Findings from the China Stroke Primary Prevention Trial (CSPPT). / Qin, Xianhui; Li, Jianping; Zhang, Yan; Chen, Dafang; Wang, Binyan; He, Mingli; Fu, Jia; Tang, Genfu; Cai, Yefeng; Shi, Xiuli; Xu, Xin; Hou, Fan Fan; Wang, Xiaobin; Huo, Yong.

In: Journal of Diabetes, Vol. 8, No. 2, 01.03.2016, p. 286-294.

Research output: Contribution to journalArticle

Qin, Xianhui ; Li, Jianping ; Zhang, Yan ; Chen, Dafang ; Wang, Binyan ; He, Mingli ; Fu, Jia ; Tang, Genfu ; Cai, Yefeng ; Shi, Xiuli ; Xu, Xin ; Hou, Fan Fan ; Wang, Xiaobin ; Huo, Yong. / Effect of folic acid supplementation on risk of new-onset diabetes in adults with hypertension in China : Findings from the China Stroke Primary Prevention Trial (CSPPT). In: Journal of Diabetes. 2016 ; Vol. 8, No. 2. pp. 286-294.
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