Effect of folic acid and vitamins B6 and B12 on microcirculatory vasoreactivity in patients with hyperhomocysteinemia

Christopher Joseph Abularrage, Anton N. Sidawy, Paul W. White, Gilbert Aidinian, Kent J. DeZee, Jonathan M. Weiswasser, Subodh Arora

Research output: Contribution to journalArticle

Abstract

Objective: Hyperhomocysteinemia (HHcy) has been identified as an independent risk factor for atherosclerotic vascular disease. The effect of high-dose folic acid or combination vitamin therapy for the treatment of HHcy on the microcirculation is unknown. The purpose of this study was to evaluate the effect of a combination of folic acid, vitamin B6, and vitamin B12 on endothelium-dependent and endothelium-independent vasoreactivity in patientswith HHcy. Methods: Baseline cutaneous microvascular vasoreactivity was measured in 20 patients with HHcy and 18 patients with normohomocysteinemia (NHcy). Laser Doppler scan imaging before and after iontophoresis of 1% acetylcholine chloride (endothelium-dependent response) and 1% sodium nitroprusside (endothelium-independent response) was performed for the measurement of forearm skin vasodilatation. Patients were then treated with 10 mg folic acid, 100 mg vitamin B6, and 1 mg vitamin B12 orally once a day for 6 months. Follow-up fasting serum homocysteine and cutaneous Laser Doppler scan imaging before and after iontophoresis were performed at 1, 2, 3, and 6 months. Statistical analysis was performed using Fisher's exact test, paired t test, and Wilcoxon matched-pairs signed-ranks test, with significance set at P

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalVascular and Endovascular Surgery
Volume41
Issue number4
DOIs
StatePublished - Aug 2007
Externally publishedYes

Fingerprint

Hyperhomocysteinemia
Vitamin B 6
Vitamin B 12
Folic Acid
Endothelium
Iontophoresis
Skin
Lasers
Nitroprusside
Homocysteine
Microcirculation
Vascular Diseases
Forearm
Vasodilation
Vitamins
Acetylcholine
Fasting
Therapeutics
Serum

Keywords

  • Folic acid
  • Homocysteine
  • Microcirculation
  • Vasoreactivity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of folic acid and vitamins B6 and B12 on microcirculatory vasoreactivity in patients with hyperhomocysteinemia. / Abularrage, Christopher Joseph; Sidawy, Anton N.; White, Paul W.; Aidinian, Gilbert; DeZee, Kent J.; Weiswasser, Jonathan M.; Arora, Subodh.

In: Vascular and Endovascular Surgery, Vol. 41, No. 4, 08.2007, p. 339-345.

Research output: Contribution to journalArticle

Abularrage, Christopher Joseph ; Sidawy, Anton N. ; White, Paul W. ; Aidinian, Gilbert ; DeZee, Kent J. ; Weiswasser, Jonathan M. ; Arora, Subodh. / Effect of folic acid and vitamins B6 and B12 on microcirculatory vasoreactivity in patients with hyperhomocysteinemia. In: Vascular and Endovascular Surgery. 2007 ; Vol. 41, No. 4. pp. 339-345.
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