Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates

Katherine E. Warren, Cynthia M. McCully, Thomas J. Walsh, Frank M. Balis

Research output: Contribution to journalArticle

Abstract

Antifungal prophylaxis in cancer patients who are undergoing chemotherapy is associated with prolonged neutropenia. We measured the effect of fluconazole on doxorubicin pharmacokinetics in nonhuman primates to determine if neutropenia is related to a pharmacokinetic interaction that delays the clearance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.

Original languageEnglish (US)
Pages (from-to)1100-1101
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume44
Issue number4
DOIs
StatePublished - Apr 2000
Externally publishedYes

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Fluconazole
Doxorubicin
Primates
Pharmacokinetics
Neutropenia
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates. / Warren, Katherine E.; McCully, Cynthia M.; Walsh, Thomas J.; Balis, Frank M.

In: Antimicrobial Agents and Chemotherapy, Vol. 44, No. 4, 04.2000, p. 1100-1101.

Research output: Contribution to journalArticle

Warren, Katherine E. ; McCully, Cynthia M. ; Walsh, Thomas J. ; Balis, Frank M. / Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates. In: Antimicrobial Agents and Chemotherapy. 2000 ; Vol. 44, No. 4. pp. 1100-1101.
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