Effect of extracorporeal membrane oxygenation on platelets in newborns

T. M. Robinson, Thomas Stephen Kickler, L. K. Walker, Paul Michael Ness, W. Bell

Research output: Contribution to journalArticle

Abstract

Objectives: To examine the effect of extracorporeal membrane oxygenation (ECMO) therapy on platelet function and number and to determine the in vivo survival of transfused platelets during ECMO. Design: Prospective study of all neonates treated with ECMO during a 6-month period. Setting: Neonatal intensive care unit in a tertiary referral center. Patients: Ten infants, .05), and a significantly (p <.05) reduced response to ristocetin and to adenosine 5'- diphosphate. Platelet adenosine triphosphate release was also significantly reduced. Single-unit platelet transfusions failed to correct platelet aggregation abnormalities. Resolution of platelet aggregation abnormalities and normalization of platelet counts occurred 8 hrs off ECMO. Conclusions: The results of these studies show that qualitative and quantitative platelet changes occur while a neonate is receiving ECMO. The survival rate of transfused platelets is reduced, and the acquired platelet dysfunction is not reversed by the transfusion of platelets with normal function while the patient is receiving ECMO.

Original languageEnglish (US)
Pages (from-to)1029-1034
Number of pages6
JournalCritical Care Medicine
Volume21
Issue number7
StatePublished - 1993

Fingerprint

Extracorporeal Membrane Oxygenation
Blood Platelets
Newborn Infant
Platelet Transfusion
Platelet Count
Platelet Aggregation
Ristocetin
Neonatal Intensive Care Units
Tertiary Care Centers
Adenosine Diphosphate
Survival Rate
Adenosine Triphosphate
Prospective Studies
Survival

Keywords

  • adenosine diphosphate
  • adenosine triphosphate
  • blood
  • critical illness
  • extracorporeal membrane oxygenation (ECMO)
  • pediatrics
  • platelet transfusion therapy
  • platelets
  • thrombocytopenia
  • transfusion

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Effect of extracorporeal membrane oxygenation on platelets in newborns. / Robinson, T. M.; Kickler, Thomas Stephen; Walker, L. K.; Ness, Paul Michael; Bell, W.

In: Critical Care Medicine, Vol. 21, No. 7, 1993, p. 1029-1034.

Research output: Contribution to journalArticle

Robinson, TM, Kickler, TS, Walker, LK, Ness, PM & Bell, W 1993, 'Effect of extracorporeal membrane oxygenation on platelets in newborns', Critical Care Medicine, vol. 21, no. 7, pp. 1029-1034.
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