Effect of Exogenous Somatostatin Infusion on Gastrointestinal Blood Flow and Hormones in the Conscious Dog

B. A. Price; B. M. Jaffe; M. J. Zinner

doi:10.1016/S0016-5085(85)80136-0

Effect of Exogenous Somatostatin Infusion on Gastrointestinal Blood Flow and Hormones in the Conscious Dog

B. A. Price, B. M. Jaffe, M. J. Zinner

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The purpose of this study was to investigate the effects of intravenous somatostatin infusion on gastrointestinal blood flow and hormone release in conscious dogs. Gastric, duodenal, jejunal, and pancreatic blood flows, quantitated using radioactive microspheres, were significantly decreased during somatostatin infusion (200 and 500 ng/kg · min), resulting in an overall 30% reduction in summed portal blood flow. Fasting blood levels of glucose fell an average of 10 mg/dl. Immunoreactive insulin, gastrin, glucagon, and pancreatic polypeptide were all profoundly suppressed by somatostatin infusion. Our studies provide one possible explanation for somatostatin's apparent effectiveness in the control of upper gastrointestinal hemorrhage.

Original language	English (US)
Pages (from-to)	80-85
Number of pages	6
Journal	Gastroenterology
Volume	88
Issue number	1
DOIs	https://doi.org/10.1016/S0016-5085(85)80136-0
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/S0016-5085(85)80136-0

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AU - Jaffe, B. M.

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Y1 - 1985

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AB - The purpose of this study was to investigate the effects of intravenous somatostatin infusion on gastrointestinal blood flow and hormone release in conscious dogs. Gastric, duodenal, jejunal, and pancreatic blood flows, quantitated using radioactive microspheres, were significantly decreased during somatostatin infusion (200 and 500 ng/kg · min), resulting in an overall 30% reduction in summed portal blood flow. Fasting blood levels of glucose fell an average of 10 mg/dl. Immunoreactive insulin, gastrin, glucagon, and pancreatic polypeptide were all profoundly suppressed by somatostatin infusion. Our studies provide one possible explanation for somatostatin's apparent effectiveness in the control of upper gastrointestinal hemorrhage.

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Effect of Exogenous Somatostatin Infusion on Gastrointestinal Blood Flow and Hormones in the Conscious Dog

Abstract

ASJC Scopus subject areas

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