Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: A randomized clinical trial

Philip D. Chilibeck, Hassanali Vatanparast, Roger Pierson, Allison Case, Olufemi Olatunbosun, Susan J. Whiting, Thomas J. Beck, Punam Pahwa, H. Jay Biem

Research output: Contribution to journalArticle

Abstract

We determined the effects of 2 years of exercise training and soy isoflavone supplementation on bone mass and lipids in postmenopausal women provided with calcium and vitamin D. Women were randomized to four groups: exercise training (Ex); isoflavone supplementation (Iso: 165 mg/d [105 mg/d aglycone equivalent]); combined Ex and Iso (ExIso); and placebo (control). Exercise included resistance training (2 days/week) and walking (4 days/week). Our primary outcomes were lumbar spine and hip bone mineral density (BMD). Secondary outcomes included hip geometry, tibia and radius speed of sound (SOS), dynamic balance (6 m backward tandem walking), blood lipids, mammography, and endometrial thickness. A total of 351 women (Ex = 86, Iso = 90, ExIso = 87, control = 88) were randomized, with 298 analyzed at 2 years (Ex = 77, Iso = 76, ExIso = 72, control = 73). There was a significant interaction for total hip BMD (p <0.001) such that ExIso had a greater rate of decrease (absolute change [95% confidence interval] = -0.018 [-0.024, -0.012] g/cm2) than either the Ex or Iso groups alone (-0.005 [-0.01, 0.001] and -0.005 [-0.011, 0.001] g/cm2, respectively). There were no differences between groups for changes in lumbar spine BMD and minimal significant changes in hip geometric properties and bone SOS. Exercise groups improved dynamic balance as measured by a decrease in backward tandem walking time over 6 m (p = 0.017). Isoflavone groups decreased low density lipoproteins (Iso: -0.20 [-0.37, -0.02] mmol/L; ExIso: -0.23 [-0.40, -0.06] mmol/L; p = 0.003) compared to non-isoflavone groups (Ex: 0.01 [-0.16, 0.18] mmol/L; control: -0.09 [-0.27, 0.08] mmol/L) and had lower adverse reports of menopausal symptoms (14% versus 33%; p = 0.01) compared to non-isoflavone groups. Isoflavone supplementation did not increase endometrial thickness or abnormal mammograms. We conclude exercise training and isoflavone supplementation maintain hip BMD compared to control, but these two interventions interfere with each other when combined. Isoflavone supplementation decreased LDL and adverse events related to menopausal symptoms.

Original languageEnglish (US)
Pages (from-to)780-793
Number of pages14
JournalJournal of Bone and Mineral Research
Volume28
Issue number4
DOIs
StatePublished - Apr 2013

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Isoflavones
Randomized Controlled Trials
Pelvic Bones
Exercise
Lipids
Bone and Bones
Bone Density
Walking
Hip
Spine
Resistance Training
Mammography
Tibia
LDL Lipoproteins
Vitamin D
Placebos
Confidence Intervals
Calcium

Keywords

  • balance
  • falls
  • femur
  • geometry
  • phytoestrogen

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women : A randomized clinical trial. / Chilibeck, Philip D.; Vatanparast, Hassanali; Pierson, Roger; Case, Allison; Olatunbosun, Olufemi; Whiting, Susan J.; Beck, Thomas J.; Pahwa, Punam; Biem, H. Jay.

In: Journal of Bone and Mineral Research, Vol. 28, No. 4, 04.2013, p. 780-793.

Research output: Contribution to journalArticle

Chilibeck, PD, Vatanparast, H, Pierson, R, Case, A, Olatunbosun, O, Whiting, SJ, Beck, TJ, Pahwa, P & Biem, HJ 2013, 'Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: A randomized clinical trial', Journal of Bone and Mineral Research, vol. 28, no. 4, pp. 780-793. https://doi.org/10.1002/jbmr.1815
Chilibeck, Philip D. ; Vatanparast, Hassanali ; Pierson, Roger ; Case, Allison ; Olatunbosun, Olufemi ; Whiting, Susan J. ; Beck, Thomas J. ; Pahwa, Punam ; Biem, H. Jay. / Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women : A randomized clinical trial. In: Journal of Bone and Mineral Research. 2013 ; Vol. 28, No. 4. pp. 780-793.
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AU - Pierson, Roger

AU - Case, Allison

AU - Olatunbosun, Olufemi

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AU - Beck, Thomas J.

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N2 - We determined the effects of 2 years of exercise training and soy isoflavone supplementation on bone mass and lipids in postmenopausal women provided with calcium and vitamin D. Women were randomized to four groups: exercise training (Ex); isoflavone supplementation (Iso: 165 mg/d [105 mg/d aglycone equivalent]); combined Ex and Iso (ExIso); and placebo (control). Exercise included resistance training (2 days/week) and walking (4 days/week). Our primary outcomes were lumbar spine and hip bone mineral density (BMD). Secondary outcomes included hip geometry, tibia and radius speed of sound (SOS), dynamic balance (6 m backward tandem walking), blood lipids, mammography, and endometrial thickness. A total of 351 women (Ex = 86, Iso = 90, ExIso = 87, control = 88) were randomized, with 298 analyzed at 2 years (Ex = 77, Iso = 76, ExIso = 72, control = 73). There was a significant interaction for total hip BMD (p <0.001) such that ExIso had a greater rate of decrease (absolute change [95% confidence interval] = -0.018 [-0.024, -0.012] g/cm2) than either the Ex or Iso groups alone (-0.005 [-0.01, 0.001] and -0.005 [-0.011, 0.001] g/cm2, respectively). There were no differences between groups for changes in lumbar spine BMD and minimal significant changes in hip geometric properties and bone SOS. Exercise groups improved dynamic balance as measured by a decrease in backward tandem walking time over 6 m (p = 0.017). Isoflavone groups decreased low density lipoproteins (Iso: -0.20 [-0.37, -0.02] mmol/L; ExIso: -0.23 [-0.40, -0.06] mmol/L; p = 0.003) compared to non-isoflavone groups (Ex: 0.01 [-0.16, 0.18] mmol/L; control: -0.09 [-0.27, 0.08] mmol/L) and had lower adverse reports of menopausal symptoms (14% versus 33%; p = 0.01) compared to non-isoflavone groups. Isoflavone supplementation did not increase endometrial thickness or abnormal mammograms. We conclude exercise training and isoflavone supplementation maintain hip BMD compared to control, but these two interventions interfere with each other when combined. Isoflavone supplementation decreased LDL and adverse events related to menopausal symptoms.

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