TY - JOUR
T1 - Effect of ethyl adenosine on myocardial flow after coronary artery occlusion
AU - Hellmann, D. B.
AU - Pitt, B.
PY - 1976
Y1 - 1976
N2 - The effect of ethyl adenosine 5' carboxylate hydrochloride (EA) was determined in 17 dogs by the radioactive microsphere technique. In both experimental and control animals, microspheres were injected 5 min before (preocclusion period), 60 min after (occlusion period), and 75 min after (saline or vasodilation period) ligation of the left anterior descending coronary artery (LAD). Ten seconds prior to the third microsphere injection, saline was administered to five control animals, and saline with 0.5 mg/kg of EA was given to 12 experimental animals. There was no significant change in myocardial blood flow after saline injection. After EA, mean arterial pressure fell 10% (P<0.001); myocardial blood flow increased 275% (P<0.001) in the nonischemic left circumflex artery (CIRC) area and increased 82% (P<0.01) in the occluded LAD area. In addition, those animals with extensive collateral development showed a significantly greater increase in collateral blood flow than those with minimal collateral development (P<0.05). Thus, EA may increase flow to ischemic areas of myocardium dependent upon the extent of preexistent collateral supply.
AB - The effect of ethyl adenosine 5' carboxylate hydrochloride (EA) was determined in 17 dogs by the radioactive microsphere technique. In both experimental and control animals, microspheres were injected 5 min before (preocclusion period), 60 min after (occlusion period), and 75 min after (saline or vasodilation period) ligation of the left anterior descending coronary artery (LAD). Ten seconds prior to the third microsphere injection, saline was administered to five control animals, and saline with 0.5 mg/kg of EA was given to 12 experimental animals. There was no significant change in myocardial blood flow after saline injection. After EA, mean arterial pressure fell 10% (P<0.001); myocardial blood flow increased 275% (P<0.001) in the nonischemic left circumflex artery (CIRC) area and increased 82% (P<0.01) in the occluded LAD area. In addition, those animals with extensive collateral development showed a significantly greater increase in collateral blood flow than those with minimal collateral development (P<0.05). Thus, EA may increase flow to ischemic areas of myocardium dependent upon the extent of preexistent collateral supply.
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U2 - 10.1152/ajplegacy.1976.231.5.1495
DO - 10.1152/ajplegacy.1976.231.5.1495
M3 - Article
C2 - 998794
AN - SCOPUS:0347651876
SN - 0002-9513
VL - 231
SP - 1495
EP - 1500
JO - American Journal of Physiology
JF - American Journal of Physiology
IS - 5 (I)
ER -