Effect of ethanol administration on the activity of hepatic lysosomal enzymes

Esteban Mezey, James John Potter, Randall A. Ammon

Research output: Contribution to journalArticle

Abstract

The activities of hepatic lysosomal enzymes were determined in rats after the acute administration of ethanol and its feeding for periods of 1 and 6 months. The acute administration of ethanol and its feeding for 1 month did not result in any changes in lysosomal enzymes. By contrast the feeding of ethanol for a period of 6 months resulted in increases in the total activities of β-glucuronidase, β-N-acetylglucosaminidase and arylsulfatase A measured in the homogenates, and in the specific activities of these enzymes plus acid phosphatase measured in the lysosomal fraction. In addition, there were increases in the free activities of β-glucuronidase and acid phosphatase measured in the homogenates. Hyaluronidase activity was not changed by ethanol feeding. The increases in lysosomal enzymes were accompanied by histologic changes consisting only of mild fatty infiltration.

Original languageEnglish (US)
Pages (from-to)2663-2667
Number of pages5
JournalBiochemical Pharmacology
Volume25
Issue number23
DOIs
StatePublished - Dec 1 1976

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Ethanol
Liver
Glucuronidase
Enzymes
Acid Phosphatase
Cerebroside-Sulfatase
Acetylglucosaminidase
Hyaluronoglucosaminidase
Infiltration
Rats

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of ethanol administration on the activity of hepatic lysosomal enzymes. / Mezey, Esteban; Potter, James John; Ammon, Randall A.

In: Biochemical Pharmacology, Vol. 25, No. 23, 01.12.1976, p. 2663-2667.

Research output: Contribution to journalArticle

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