Effect of ergot derivatives on post-decapitation convulsions

Robert E. Hruska, Ellen K. Silbergeld

Research output: Contribution to journalArticlepeer-review

Abstract

Several ergot derivatives (lergotrile, Sandoz compound 29-712, and metergoline) prolonged the latency and shortened the duration of the post-decapitation convulsions in rats. Other ergot derivatives, such as bromocriptine and lisuride, were ineffective. The decrease in the duration of the post-decapitation convulsion was related to the ratio of the in vitro inhibition of norepinephrine and dopamine receptor binding.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalCommunications In Psychopharmacology
Volume4
Issue number1
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Effect of ergot derivatives on post-decapitation convulsions'. Together they form a unique fingerprint.

Cite this