Effect of enterotoxins of Vibrio cholerae, Escherichia coli, and Shigella dysenteriae type 1 on fluid and electrolyte transport in the colon

M. Donowitz, H. J. Binder

Research output: Contribution to journalArticlepeer-review

Abstract

Experiments were designed to determine whether the enterotoxins of Vibrio cholerae, E. coli, and Shigella dysenteriae type 1 alter the movement of fluid and electrolytes in the rat cecum. Net secretion of water as sodium were observed after incubation of 1.67 x 10-5 μg of purified cholera toxin (choleragen)/ml for 18 hr or of 50 μg/ml for 3 hr. The effect of choleragen on cecal transport of water and electrolytes was related to the dose. In addition, choleragen increased cecal mucosal content of adenosine 3':5' cyclic phosphate but did not alter the histology of the cecum. The results demonstrate that the colon responds to choleragen in a manner similar to that of other tissues. In contrast, the enterotoxins of both E. coli and S. dysenteriae type 1 failed to affect cecal transport of water and electrolytes. These observations may explain several phenomena associated with the diarrhea produced by bacterial enterotoxins.

Original languageEnglish (US)
Pages (from-to)135-143
Number of pages9
JournalJournal of Infectious Diseases
Volume134
Issue number2
DOIs
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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