TY - JOUR
T1 - Effect of dispersion of vessel diameters and lengths in stochastic networks. II. Modeling of microvascular hematocrit distribution
AU - Levin, M.
AU - Dawant, B.
AU - Popel, A. S.
N1 - Funding Information:
We thank Dr. William Federspiel for reading the manuscripta nd making critical comments,M s. Leigh Hollyer for help in preparationo f the manuscript,a nd Ms. Alice Zilcha for typing. Supported by NIH Grants HL 17421,H L 18292,a nd HL 26901.P arts of this work were presenteda t the Microcirculatory Society Meeting in New Orleans (Microvasc. RPS. 23, 263, 1982)a nd at the XII European Conference on Microcirculation in Jerusalem (Int. J. Microcirculation Clin. Exp. 1, 310- 311, 1982).
PY - 1986/3
Y1 - 1986/3
N2 - A microvascular network model described in the preceding paper (B. Dawant, M. Levin, and A. s. Popel, 1986, Microvasc. Res. 31, 203-222) featuring random distribution of vessel diameters and lengths, is extended to calculate the distributions of red blood cell flux and discharge hematocrit throughout the network. A relationship between red blood cell fluxes and blood flow rates at vascular bifurcations is incorporated into the model, and the effect of the form of this relationship on RBC distribution is investigated. The mean capillary discharge hematocrit is sensitive to the variation of parameters describing this relationship; thus detailed experimental information is required for bifurcations of different sizes and types.
AB - A microvascular network model described in the preceding paper (B. Dawant, M. Levin, and A. s. Popel, 1986, Microvasc. Res. 31, 203-222) featuring random distribution of vessel diameters and lengths, is extended to calculate the distributions of red blood cell flux and discharge hematocrit throughout the network. A relationship between red blood cell fluxes and blood flow rates at vascular bifurcations is incorporated into the model, and the effect of the form of this relationship on RBC distribution is investigated. The mean capillary discharge hematocrit is sensitive to the variation of parameters describing this relationship; thus detailed experimental information is required for bifurcations of different sizes and types.
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U2 - 10.1016/0026-2862(86)90036-1
DO - 10.1016/0026-2862(86)90036-1
M3 - Article
C2 - 3702770
AN - SCOPUS:0022585341
VL - 31
SP - 223
EP - 234
JO - Microvascular Research
JF - Microvascular Research
SN - 0026-2862
IS - 2
ER -