Effect of dioctyl sodium sulfosuccinate on colonic fluid and electrolyte movement

Mark Donowitz, H. J. Binder

Research output: Contribution to journalArticle

Abstract

These studies evaluated the effect of dioctyl sodium sulfosuccinate (DSS), a detergent and the active ingredient of some commercially available stool softeners, on intestinal fluid and electrolyte movement. DSS produced water, sodium and chloride secretion into the in vivo rat cecum. This secretion readily reverted to net absorption following replacement of DSS by isotonic saline. In in vitro studies, DSS increased the short circuit current and diminished sodium absorption. The increase in short circuit current was not observed either when HCO3 and chloride were absent from the incubation solution or when theophylline was present. DSS also significantly increased mucosal cyclic adenosine monophosphate levels. These results which are similar to previous studies of the effect of cholera enterotoxin on ileal mucosa and bile salts on colonic mucosa are consistent with the proposal that DSS stimulates fluid and electrolyte secretion which is mediated by increased mucosal cyclic adenosine 3':5' monophosphate.

Original languageEnglish (US)
Pages (from-to)941-950
Number of pages10
JournalGastroenterology
Volume69
Issue number4
StatePublished - 1975
Externally publishedYes

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Dioctyl Sulfosuccinic Acid
Electrolytes
Mucous Membrane
Fluids and Secretions
Cecum
Theophylline
Bile Acids and Salts
Sodium Chloride
Detergents
Cyclic AMP
Adenosine
Chlorides
Sodium
Water

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effect of dioctyl sodium sulfosuccinate on colonic fluid and electrolyte movement. / Donowitz, Mark; Binder, H. J.

In: Gastroenterology, Vol. 69, No. 4, 1975, p. 941-950.

Research output: Contribution to journalArticle

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