Effect of dihydrotestosterone on rat liver alcohol dehydrogenase activity

Research output: Contribution to journalArticle

Abstract

Castration was previously demonstrated to result in an increase in liver alcohol dehydrogenase and in rates of ethanol elimination in male rats. In this study, the effect of dihydrotestosterone, which is a more potent androgen than testosterone in the rat, was determined on liver alcohol dehydrogenase and ethanol elimination in the castrated rat. Dihydrotestosterone was found to be a substrate of liver alcohol dehydrogenase in the reductive direction and a competitive inhibitor of ethanol oxidation by the enzyme. Also, the administration of a single dose of dihydrotestosterone inhibited liver alcohol dehydrogenase 4 hr after the injection, but this effect was not persistent at later intervals following injection. This transient in vivo inhibition of liver alcohol dehydrogenase was associated with a delay in ethanol elimination. The microsomal ethanol-oxidizing enzyme system was found to play no role in the changes in ethanol elimination observed after castration and dihydrotestosterone administration since its activity remained unchanged. These studies provide further evidence of an effect of androgenic steroids on liver alcohol dehydrogenase activity and ethanol metabolism.

Original languageEnglish (US)
Pages (from-to)359-365
Number of pages7
JournalHepatology
Volume2
Issue number3
StatePublished - 1982

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Dihydrotestosterone
Alcohol Dehydrogenase
Ethanol
Liver
Castration
Injections
Enzymes
Androgens
Testosterone
Steroids

ASJC Scopus subject areas

  • Hepatology

Cite this

Effect of dihydrotestosterone on rat liver alcohol dehydrogenase activity. / Mezey, Esteban; Potter, James John.

In: Hepatology, Vol. 2, No. 3, 1982, p. 359-365.

Research output: Contribution to journalArticle

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