Effect of dihomo-γ-linolenic acid on the canine pulmonary vascular bed

A. L. Hyman, E. W. Spannhake, B. M. Chapnick

Research output: Contribution to journalArticle

Abstract

The effect of dihomo-γ-linolenic acid (DGLA), the precursor of the monoenoic prostaglandins (PG), F1(α) and E1, on the pulmonary vascular bed of the intact dog was studied under conditions of controlled pulmonary blood flow. DGLA increased pulmonary vascular resistance in a dose-related manner by constricting intrapulmonary veins and upstream segments, presumably pulmonary arteries. Intrapulmonary injection of DGLA also increased transpulmonary airway pressure, presumably by increasing airway resistance and decreasing lung compliance or both. The vasoconstrictor response, however, was independent of changes in transpulmonary pressure since similar pressor responses were obtained in ventilated and nonventilated lungs. Further, the response was not dependent on factors or elements in whole blood, since the increase in pulmonary vascular resistance occurred during perfusion with saline or dextran and was enhanced in these media. Conversion of DGLA to PGs by a lung cyclo-oxygenase appears to mediate the response, since it was blocked by indomethacin and does not occur with injection of nonprecursor long-chain fatty acids. These data suggest that the response to DGLA is due to formation of vasoactive products in the monoenoic PG pathway.

Original languageEnglish (US)
Pages (from-to)H133-H138
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume3
Issue number2
StatePublished - Jan 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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