Effect of dietary fiber intake on lipoprotein cholesterol levels independent of estradiol in healthy premenopausal women

Sunni L. Mumford, Enrique F. Schisterman, Anna Maria Siega-Riz, Audrey J. Gaskins, Jean Wactawski-Wende, Tyler J. Vanderweele

Research output: Contribution to journalArticle

Abstract

High-fiber diets are associated with improved lipid profiles. However, pre- and postmenopausal women respond differently to fiber intake, suggesting that endogenous estradiol mediates the effect. The authors' objective was to determine the direct effect of fiber intake on lipoprotein cholesterol levels independent of estradiol among premenopausal women. The BioCycle Study, a prospective cohort study conducted at the State University of New York at Buffalo from 2005 to 2007, followed 259 healthy women for up to 2 complete menstrual cycles. Serum lipoprotein and hormone levels were measured at 16 visits timed using fertility monitors. Fiber intake was assessed by 8 24-hour recalls. Marginal structural models with inverse probability weights for both lipoprotein and estradiol levels were used to estimate controlled direct effects of the highest category of fiber intake (≥22 g/day vs.

Original languageEnglish (US)
Pages (from-to)145-156
Number of pages12
JournalAmerican Journal of Epidemiology
Volume173
Issue number2
DOIs
StatePublished - Jan 15 2011
Externally publishedYes

Keywords

  • cholesterol
  • dietary fiber
  • estradiol
  • lipoproteins
  • menstrual cycle

ASJC Scopus subject areas

  • Epidemiology

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  • Cite this

    Mumford, S. L., Schisterman, E. F., Siega-Riz, A. M., Gaskins, A. J., Wactawski-Wende, J., & Vanderweele, T. J. (2011). Effect of dietary fiber intake on lipoprotein cholesterol levels independent of estradiol in healthy premenopausal women. American Journal of Epidemiology, 173(2), 145-156. https://doi.org/10.1093/aje/kwq388