Abstract
Purpose. We compared the efficacy of topical medicines to modulate arachidonic acid metabolism in rabbit cornea following excimer ablation. Methods. Rabbits were subjected to photorefractive keratectomy on a VISX Twenty-Twenty excimer laser. Metabolites were measured by enzyme-immune assay. Results. Following excimer ablation, prostaglandin E2 and leukocyte infiltration increased in the cornea relative to untreated control (p<.0001 and p=.037 ANOVA, respectively). Topical fluorometholone and diclofenac significantly reduced prostaglandin E2 levels relative to vehicle control (p=.001 and p= .007, respectively). Corneas treated with diclofenac had higher levels of leukocyte infiltration than those treated with ketorolac (p=.006). No changes in leukotriene B4 levels were detected in this model. Conclusion. Topical anti-inflammatory medications tend to lower prostaglandin E2. This result may account for analgesia provided by these medicines following photorefractive keratectomy.
Original language | English (US) |
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Pages (from-to) | S197 |
Journal | Investigative Ophthalmology and Visual Science |
Volume | 37 |
Issue number | 3 |
State | Published - Feb 15 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience