Effect of diclofenac, ketorolac, and fluorometholone on arachidonic acid metabolites following excimer laser corneal surgery

Andrew F. Phillips, Seiji Hayashi, Berthold Seitz, Won Ryang Wee, Peter J. McDonnell

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To compare the ability of several topical anti-inflammatory agents to modulate the production of prostaglandin E2 after excimer laser ablation in rabbit cornea. Methods: Adult New Zealand white rabbits were subjected to phototherapeutic keratectomy with a commercially available excimer laser. Prostaglandin E2 and leukotriene B4 were detected by enzyme- linked immunoassay, and leukocyte infiltration was determined histologically. Results: Prostaglandin E2 and leukocyte infiltration in creased in the cornea after excimer ablation. Treatment with topical fluorometholone and diclofenac sodium significantly reduced prostaglandin E2 levels. Corneas treated with diclofenac had significantly higher levels of leukocyte infiltration than those treated with ketorolac tromethamine. No changes in leukotriene B4 levels were detected in this model. Conclusions: As a group, topical anti-inflammatory medications tend to lower prostaglandin E2 levels in rabbit corneas subjected to excimer ablation, but differ in their ability to reduce polymorphonuclear leukocyte infiltration. Further work is needed in this model to understand how these drugs alter leukocyte infiltration of the remaining stromal bed.

Original languageEnglish (US)
Pages (from-to)1495-1498
Number of pages4
JournalArchives of ophthalmology
Volume114
Issue number12
DOIs
StatePublished - Dec 1996
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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