Effect of Cyproheptadine on Asthmatic Children: Study of Appetite, Weight Gain, and Linear Growth

Arnold F. Lavenstein, Eleanora P. Dacaney, Louis Lasagna, Thomas E. Van Metre

Research output: Contribution to journalArticle

Abstract

Cyproheptadine, an antagonist of histamine and serotonin, was compared with chlorpheniramine in a double blind study of 28 asthmatic children. Patients receiving cyproheptadine showed a marked increase in appetite, an associated weight gain, and an accelerated linear growth rate. The weight gain was apparently a reflection of simple exogenous obesity; there was no evidence of fluid retention. These effects of cyproheptadine could not be ascribed to a superior antihistaminic or antiasthmatic activity of the compound, since cyproheptadine and chlorpheniramine appeared equal in these respects.

Original languageEnglish (US)
Pages (from-to)912-916
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Volume180
Issue number11
DOIs
StatePublished - Jun 16 1962

ASJC Scopus subject areas

  • Medicine(all)

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