TY - JOUR
T1 - Effect of Cyproheptadine on Asthmatic Children
T2 - Study of Appetite, Weight Gain, and Linear Growth
AU - Lavenstein, Arnold F.
AU - Dacaney, Eleanora P.
AU - Lasagna, Louis
AU - Van Metre, Thomas E.
PY - 1962/6/16
Y1 - 1962/6/16
N2 - Cyproheptadine, an antagonist of histamine and serotonin, was compared with chlorpheniramine in a double blind study of 28 asthmatic children. Patients receiving cyproheptadine showed a marked increase in appetite, an associated weight gain, and an accelerated linear growth rate. The weight gain was apparently a reflection of simple exogenous obesity; there was no evidence of fluid retention. These effects of cyproheptadine could not be ascribed to a superior antihistaminic or antiasthmatic activity of the compound, since cyproheptadine and chlorpheniramine appeared equal in these respects.
AB - Cyproheptadine, an antagonist of histamine and serotonin, was compared with chlorpheniramine in a double blind study of 28 asthmatic children. Patients receiving cyproheptadine showed a marked increase in appetite, an associated weight gain, and an accelerated linear growth rate. The weight gain was apparently a reflection of simple exogenous obesity; there was no evidence of fluid retention. These effects of cyproheptadine could not be ascribed to a superior antihistaminic or antiasthmatic activity of the compound, since cyproheptadine and chlorpheniramine appeared equal in these respects.
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U2 - 10.1001/jama.1962.03050240008002
DO - 10.1001/jama.1962.03050240008002
M3 - Article
C2 - 14462919
AN - SCOPUS:0010613982
SN - 0098-7484
VL - 180
SP - 912
EP - 916
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 11
ER -