Effect of cyclosporin A (CyA) on the immunopathological lesion of the labial minor salivary glands from patients with Sjogren's syndrome

Y. A. Dalavanga, B. Detrick, J. J. Hooks, A. A. Drosos, H. M. Moutsopoulos

Research output: Contribution to journalArticlepeer-review

Abstract

Labial minor salivary gland biopsy specimens from 14 patients with Sjogren's syndrome treated either with cyclosporin A (CyA) or placebo (5 mg/kg body weight day for six months) were studied to determine T lymphocyte subsets and HLA-DR antigen expression using the avidin-biotin-peroxidase technique. In all CyA treated patients we observed a decrease in the number of T lymphocytes and in the number of T helper cells, while the percentage of T suppressor cells and B cells was the same in both treated and untreated groups. It was also shown that the HLA-DR antigen expression on the epithelial cells was eliminated in the CyA treated patients. These findings suggest that the HLA-DR antigen expression on the epithelial cells is the result rather than the triggering factor of this T cell mediated process and is probably related to decreased lymphokine production by activated T lymphocytes.

Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalAnnals of the rheumatic diseases
Volume46
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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