Effect of cyclic strain on inflamed ligament cells propagated on flexible silicone membrane

K. Lahiji, A. V. Polotsky, T. Johnson, D. S. Hungerford, C. G. Frondoza

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The response of anterior cruciate ligament cells plated on flexible silicone membranes to biaxial cyclic strain was investigated. The ligament cells isolated from two patients were propagated in monolayer cultures and the cells were induced inflammation by treating them with IL-1β. These cells when subjected to cyclic strain, showed decreased proliferative capacity and gene marker expression compared to their static controls. The results suggested that cyclic strain exacerbates the inflammatory effect of IL-1β thereby impeding phenotypic expression of ligament cells.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Effect of cyclic strain on inflamed ligament cells propagated on flexible silicone membrane'. Together they form a unique fingerprint.

  • Cite this

    Lahiji, K., Polotsky, A. V., Johnson, T., Hungerford, D. S., & Frondoza, C. G. (2004). Effect of cyclic strain on inflamed ligament cells propagated on flexible silicone membrane. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).