TY - JOUR
T1 - Effect of continued oral feeding on clinical and nutritional outcomes of acute diarrhea in children
AU - Brown, Kenneth H.
AU - Gastañaduy, Arturo S.
AU - Saavedra, Jose M.
AU - Lembcke, Jorge
AU - Rivas, Diana
AU - Robertson, Alastair D.
AU - Yolken, Robert
AU - Bradley Sack, R.
N1 - Funding Information:
An estimated one billion episodes of acute diarrheal diseases occur annually in the developing world. ~ These illnesses result in more than 4.6 million deaths each year Supported by the Diarrheal Disease Control Programme of the World Health Organization (File reference No. C6/181/67-A), with additional contributions from Nestle, S.A., Vevey, Switzer-lan d, and from the Office of Nutrition, U.S. Agency for International Development (Dietary Management of Diarrheal Disease Program, Cooperative Agreement No. DAN-1010-A-00-5119-00). Submitted for publication Aug. 5, 1987; accepted Sept. 18, 1987. Reprint requests: K. H. Brown, MD, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205.
PY - 1988/2
Y1 - 1988/2
N2 - One hundred twenty-eight nonmalnourished male patients between 3 and 36 months of age were randomly assigned to receive one of four lactose-free dietary treatments to determine the effect of dietary therapy on the severity and nutritional outcome of diarrheal illness. Group 1 received a formula diet composed of casein, sucrose, dextrin with maltose (Dextri-Maltose), and vegetable oll to provide 110 kcal/kg body weight/d (CSO-110). Group 2 received CSO to provide 55 kcal/kg/d (CSO-55) for 2 days and then CSO-110. Group 3 received only oral glucose-electrolyte solution (GES) for 2 days, CSO-55 for the next 2 days, and then CSO-110. Group 4 received the same diets as Group 3 except that only intravenous GES was used for the first 2 days. The GES maintenance solutions provided 24 to 30 kcal/kg/d. Therapeutic success rates were similar among dietary groups, ranging from 90% to 97%. Fecal excretion was initially lower in group 4 (P<0.05) but was similar initially among groups treated orally and among all four groups beginning on day 3. Net apparent absorption of nitrogen, fat, carbohydrate, and total energy; retention of nitrogen; and increments in body weight, arm circumference, and skin-fold thicknesses were positively related to the amounts of dietary energy consumed. Thus continued oral feeding with the CSO diets during the early phase of therapy yielded improved nutritional results.
AB - One hundred twenty-eight nonmalnourished male patients between 3 and 36 months of age were randomly assigned to receive one of four lactose-free dietary treatments to determine the effect of dietary therapy on the severity and nutritional outcome of diarrheal illness. Group 1 received a formula diet composed of casein, sucrose, dextrin with maltose (Dextri-Maltose), and vegetable oll to provide 110 kcal/kg body weight/d (CSO-110). Group 2 received CSO to provide 55 kcal/kg/d (CSO-55) for 2 days and then CSO-110. Group 3 received only oral glucose-electrolyte solution (GES) for 2 days, CSO-55 for the next 2 days, and then CSO-110. Group 4 received the same diets as Group 3 except that only intravenous GES was used for the first 2 days. The GES maintenance solutions provided 24 to 30 kcal/kg/d. Therapeutic success rates were similar among dietary groups, ranging from 90% to 97%. Fecal excretion was initially lower in group 4 (P<0.05) but was similar initially among groups treated orally and among all four groups beginning on day 3. Net apparent absorption of nitrogen, fat, carbohydrate, and total energy; retention of nitrogen; and increments in body weight, arm circumference, and skin-fold thicknesses were positively related to the amounts of dietary energy consumed. Thus continued oral feeding with the CSO diets during the early phase of therapy yielded improved nutritional results.
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U2 - 10.1016/S0022-3476(88)80055-6
DO - 10.1016/S0022-3476(88)80055-6
M3 - Article
C2 - 3339500
AN - SCOPUS:0023877912
SN - 0022-3476
VL - 112
SP - 191
EP - 200
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 2
ER -