Effect of comorbidity on post-treatment quality of life scores in patients with head and neck squamous cell carcinoma

Christine Gourin, Brian J. Boyce, Creighton C. Vaught, Lori M. Burkhead, Robert H. Podolsky

Research output: Contribution to journalArticle


Objectives/Hypothesis: To determine the effect of comorbidity on 1-year post-treatment quality of life (QOL) in patients with head and neck squamous cell cancer (HNSCC). Methods: One hundred twenty-five previously untreated HNSCC patients participated in longitudinal QOL analysis over a 28-month period. The University of Washington QOL questionnaire, Performance Status Scale, and Karnofsky score were used to measure QOL. Generalized estimating equations were used to analyze the effects of patient variables and their interaction with time. Results: The majority of patients (74%) had advanced stage (III/IV) disease; advanced comorbidity was present in 30%. Early tumor, node, metastases (TNM) stage was associated with significantly greater ecreases in 1-year chewing and swallowing scores (P

Original languageEnglish (US)
Pages (from-to)907-914
Number of pages8
Issue number5
Publication statusPublished - May 2009



  • Comorbidity
  • Head and neck neoplasms
  • Quality of life
  • Squamous cell cancer
  • Treatment

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

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