Effect of cocaine on coronary artery dimensions in atherosclerotic coronary artery disease

Enhanced vasoconstriction at sites of significant stenoses

Eduardo D. Flores, Richard A. Lange, Ricardo G. Cigarroa, L. David Hillis

Research output: Contribution to journalArticle

Abstract

Cocaine increases myocardial oxygen demand and paradoxically decreases oxygen supply by reducing coronary blood flow. Such "inappropriate" vasoconstriction also occurs with exercise, which causes intense vasoconstriction of coronary artery segments narrowed by atherosclerosis. This study was done to assess the cocaine-induced change in vasomotor tone of diseased and nondiseased coronary artery segments. In 18 patients (15 men, 3 women, aged 35 to 67 years), coronary artery areas in diseased and nondiseased segments were quantitated before and 15 min after administration of intranasal saline solution (6 patients) or cocaine (2 mg/kg body weight) (12 patients). No variables changed after intake of the saline solution. In response to cocaine, the luminal areas of diseased and nondiseased segments decreased, but the magnitude of vasoconstriction was greater in the diseased segments (mean ± SD 29 ± 23% versus 13 ± 8%, p <0.05). Thus, cocaine causes vasoconstriction of diseased and nondiseased coronary artery segments, but its effect is particularly marked in the former.

Original languageEnglish (US)
Pages (from-to)74-79
Number of pages6
JournalJournal of the American College of Cardiology
Volume16
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

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Vasoconstriction
Cocaine
Coronary Artery Disease
Coronary Vessels
Pathologic Constriction
Sodium Chloride
Oxygen
Intranasal Administration
Atherosclerosis
Body Weight
Exercise

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Effect of cocaine on coronary artery dimensions in atherosclerotic coronary artery disease : Enhanced vasoconstriction at sites of significant stenoses. / Flores, Eduardo D.; Lange, Richard A.; Cigarroa, Ricardo G.; Hillis, L. David.

In: Journal of the American College of Cardiology, Vol. 16, No. 1, 1990, p. 74-79.

Research output: Contribution to journalArticle

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