Effect of canal plugging on quadrupedal locomotion in monkey

Bernard Cohen, Yongqing Xiang, Sergei B. Yakushin, Mikhail Kunin, Theodore Raphan, Lloyd Minor, Charles C. Della Santina

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The vestibular system plays an important role in controling gait, but where in the labyrinths relevant activity arises is largely unknown. After the semicircular canals are plugged, low frequency (0.01-2 Hz) components of the angular vestibulo-ocular reflex (aVOR) and angular vestibulo-collic reflex (aVCR) are lost, but high frequency (3-20 Hz) components remain. We determined how loss of low frequency canal afference affects limb and head movements during quadrupedal locomotion. Head, body, and limb movements were recorded in three dimensions (3-D) in a cynomolgus monkey with a motion detection system, while the animal walked on a treadmill. All six canals were plugged, reducing the canal time constants from ≈4.0 sec to ≈0.07 sec. Major changes in the control of the limbs occurred after surgery. Fore and hind limbs were held farther from the body, producing a broad-based gait. Swing-phase trajectories were inaccurate, and control of medial-lateral limb movement was erratic. These changes in gait were present immediately after surgery, as well as 15 months later, when the animal had essentially recovered. Thus, control of the limbs in the horizontal plane was defective after loss of the low-frequency semicircular canal input and never recovered. Cycle-averaged pitch and roll head rotations, and 3-D head translations were also significantly larger and more erratic after than before surgery. Head rotations in yaw could not be quantified due to intrusion of voluntary head turns. These findings indicate that the semicircular canals provide critical low frequency information to maximize the accuracy of stepping and stabilize the head during normal quadrupedal locomotion.

Original languageEnglish (US)
Title of host publicationBasic and Clinical Aspects of Vertigo and Dizziness
PublisherBlackwell Publishing Inc.
Pages89-96
Number of pages8
ISBN (Print)9781573317177
DOIs
StatePublished - May 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1164
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Angular vestibulo-collic reflex (aVCR)
  • Cynomolgus
  • Semicircular canals
  • Swing-phase dynamics
  • Vestibular
  • Walking

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Cohen, B., Xiang, Y., Yakushin, S. B., Kunin, M., Raphan, T., Minor, L., & Della Santina, C. C. (2009). Effect of canal plugging on quadrupedal locomotion in monkey. In Basic and Clinical Aspects of Vertigo and Dizziness (pp. 89-96). (Annals of the New York Academy of Sciences; Vol. 1164). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.03845.x