Effect of buffer on the immune response to trivalent oral poliovirus vaccine in Bangladesh: A community based randomized controlled trial

Subhash Chandir, Kabir U. Ahamed, Abdullah H. Baqui, Roland W. Sutter, Hiromasa Okayasu, Mark A. Pallansch, Mark S. Oberste, Lawrence H. Moulton, Neal A. Halsey

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Polio eradication efforts have been hampered by low responses to trivalent oral poliovirus vaccine (tOPV) in some developing countries. Since stomach acidity may neutralize vaccine viruses, we assessed whether administration of a buffer solution could improve the immunogenicity of tOPV.

Methods: Healthy infants 4-6 weeks old in Sylhet, Bangladesh, were randomized to receive tOPV with or without a sodium bicarbonate and sodium citrate buffer at age 6, 10, and 14 weeks. Levels of serum neutralizing antibodies for poliovirus types 1, 2, and 3 were measured before and after vaccination, at 6 and 18 weeks of age, respectively.

Findings: Serologic response rates following 3 doses of tOPV for buffer recipients and control infants were 95% and 88% (P =. 065), respectively, for type 1 poliovirus; 95% and 97% (P =. 543), respectively, for type 2 poliovirus; and 90% and 89% (P =. 79), respectively, for type 3 poliovirus.

Conclusions: Administration of a buffer solution prior to vaccination was not associated with statistically significant increases in the immune response to tOPV; however, a marginal 7% increase (P =. 065) in serologic response to poliovirus type 1 was observed. Clinical Trials Registration: NCT01579825.

Original languageEnglish (US)
Pages (from-to)S390-S397
JournalJournal of Infectious Diseases
Volume210
DOIs
StatePublished - Nov 1 2014

Keywords

  • buffer
  • immunogenicity
  • oral poliovirus vaccine
  • serologic response

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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