Effect of brimonidine 0.5% on intraocular pressure spikes following 360° argon laser trabeculoplasty

Alan L. Robin, R. David, L. Shani, H. Barnebey, C. E. Clevenger, T. J. Zimmerman, G. Nardin, S. B. Hersh, J. C. Morrison, G. L. Spaeth, L. J. Katz, H. F. Perell, L. I. Siegel, R. A. Lewis, J. C. Henry, A. L. Coleman, D. A. Lee, M. C. Stiles, M. S. Passo

Research output: Contribution to journalArticle

Abstract

Background and Objective: Brimonidine tartrate 0.5%, a topical alpha2-adrenergic agonist, was administered before and after argon laser trabeculoplasty (ALT) to evaluate its efficacy against postoperative intraocular pressure (IOP) spikes. Patients and Methods: Two randomized, double-masked, vehicle-controlled investigations evaluated four treatment regimens in 471 patients undergoing ALT for glaucoma or ocular hypertension. The combined results are presented. Results: IOP elevations ≥ 10 mmHg occured in 1% (1/122) of the patients who received brimonidine before and after ALT; in 2% (2/119) of those receiving brimonidine before and vehicle after; in 1% (1/114) of those receiving vehicle before and brimonidine after; and in 23% (27/116) of those receiving vehicle before and after (P <.001). Conclusion: The brimonidine regimens were generally effective and well-tolerated ocularly and systemically.

Original languageEnglish (US)
Pages (from-to)404-409
Number of pages6
JournalOphthalmic Surgery and Lasers
Volume26
Issue number5
StatePublished - 1995
Externally publishedYes

Fingerprint

Trabeculectomy
Argon
Intraocular Pressure
Lasers
Adrenergic alpha-2 Receptor Agonists
Ocular Hypertension
Glaucoma
Brimonidine Tartrate

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Robin, A. L., David, R., Shani, L., Barnebey, H., Clevenger, C. E., Zimmerman, T. J., ... Passo, M. S. (1995). Effect of brimonidine 0.5% on intraocular pressure spikes following 360° argon laser trabeculoplasty. Ophthalmic Surgery and Lasers, 26(5), 404-409.

Effect of brimonidine 0.5% on intraocular pressure spikes following 360° argon laser trabeculoplasty. / Robin, Alan L.; David, R.; Shani, L.; Barnebey, H.; Clevenger, C. E.; Zimmerman, T. J.; Nardin, G.; Hersh, S. B.; Morrison, J. C.; Spaeth, G. L.; Katz, L. J.; Perell, H. F.; Siegel, L. I.; Lewis, R. A.; Henry, J. C.; Coleman, A. L.; Lee, D. A.; Stiles, M. C.; Passo, M. S.

In: Ophthalmic Surgery and Lasers, Vol. 26, No. 5, 1995, p. 404-409.

Research output: Contribution to journalArticle

Robin, AL, David, R, Shani, L, Barnebey, H, Clevenger, CE, Zimmerman, TJ, Nardin, G, Hersh, SB, Morrison, JC, Spaeth, GL, Katz, LJ, Perell, HF, Siegel, LI, Lewis, RA, Henry, JC, Coleman, AL, Lee, DA, Stiles, MC & Passo, MS 1995, 'Effect of brimonidine 0.5% on intraocular pressure spikes following 360° argon laser trabeculoplasty', Ophthalmic Surgery and Lasers, vol. 26, no. 5, pp. 404-409.
Robin, Alan L. ; David, R. ; Shani, L. ; Barnebey, H. ; Clevenger, C. E. ; Zimmerman, T. J. ; Nardin, G. ; Hersh, S. B. ; Morrison, J. C. ; Spaeth, G. L. ; Katz, L. J. ; Perell, H. F. ; Siegel, L. I. ; Lewis, R. A. ; Henry, J. C. ; Coleman, A. L. ; Lee, D. A. ; Stiles, M. C. ; Passo, M. S. / Effect of brimonidine 0.5% on intraocular pressure spikes following 360° argon laser trabeculoplasty. In: Ophthalmic Surgery and Lasers. 1995 ; Vol. 26, No. 5. pp. 404-409.
@article{3bbcf0022c2f477ab9794a1b1e7df0fc,
title = "Effect of brimonidine 0.5{\%} on intraocular pressure spikes following 360° argon laser trabeculoplasty",
abstract = "Background and Objective: Brimonidine tartrate 0.5{\%}, a topical alpha2-adrenergic agonist, was administered before and after argon laser trabeculoplasty (ALT) to evaluate its efficacy against postoperative intraocular pressure (IOP) spikes. Patients and Methods: Two randomized, double-masked, vehicle-controlled investigations evaluated four treatment regimens in 471 patients undergoing ALT for glaucoma or ocular hypertension. The combined results are presented. Results: IOP elevations ≥ 10 mmHg occured in 1{\%} (1/122) of the patients who received brimonidine before and after ALT; in 2{\%} (2/119) of those receiving brimonidine before and vehicle after; in 1{\%} (1/114) of those receiving vehicle before and brimonidine after; and in 23{\%} (27/116) of those receiving vehicle before and after (P <.001). Conclusion: The brimonidine regimens were generally effective and well-tolerated ocularly and systemically.",
author = "Robin, {Alan L.} and R. David and L. Shani and H. Barnebey and Clevenger, {C. E.} and Zimmerman, {T. J.} and G. Nardin and Hersh, {S. B.} and Morrison, {J. C.} and Spaeth, {G. L.} and Katz, {L. J.} and Perell, {H. F.} and Siegel, {L. I.} and Lewis, {R. A.} and Henry, {J. C.} and Coleman, {A. L.} and Lee, {D. A.} and Stiles, {M. C.} and Passo, {M. S.}",
year = "1995",
language = "English (US)",
volume = "26",
pages = "404--409",
journal = "Ophthalmic Surgery Lasers and Imaging Retina",
issn = "2325-8160",
publisher = "Slack Incorporated",
number = "5",

}

TY - JOUR

T1 - Effect of brimonidine 0.5% on intraocular pressure spikes following 360° argon laser trabeculoplasty

AU - Robin, Alan L.

AU - David, R.

AU - Shani, L.

AU - Barnebey, H.

AU - Clevenger, C. E.

AU - Zimmerman, T. J.

AU - Nardin, G.

AU - Hersh, S. B.

AU - Morrison, J. C.

AU - Spaeth, G. L.

AU - Katz, L. J.

AU - Perell, H. F.

AU - Siegel, L. I.

AU - Lewis, R. A.

AU - Henry, J. C.

AU - Coleman, A. L.

AU - Lee, D. A.

AU - Stiles, M. C.

AU - Passo, M. S.

PY - 1995

Y1 - 1995

N2 - Background and Objective: Brimonidine tartrate 0.5%, a topical alpha2-adrenergic agonist, was administered before and after argon laser trabeculoplasty (ALT) to evaluate its efficacy against postoperative intraocular pressure (IOP) spikes. Patients and Methods: Two randomized, double-masked, vehicle-controlled investigations evaluated four treatment regimens in 471 patients undergoing ALT for glaucoma or ocular hypertension. The combined results are presented. Results: IOP elevations ≥ 10 mmHg occured in 1% (1/122) of the patients who received brimonidine before and after ALT; in 2% (2/119) of those receiving brimonidine before and vehicle after; in 1% (1/114) of those receiving vehicle before and brimonidine after; and in 23% (27/116) of those receiving vehicle before and after (P <.001). Conclusion: The brimonidine regimens were generally effective and well-tolerated ocularly and systemically.

AB - Background and Objective: Brimonidine tartrate 0.5%, a topical alpha2-adrenergic agonist, was administered before and after argon laser trabeculoplasty (ALT) to evaluate its efficacy against postoperative intraocular pressure (IOP) spikes. Patients and Methods: Two randomized, double-masked, vehicle-controlled investigations evaluated four treatment regimens in 471 patients undergoing ALT for glaucoma or ocular hypertension. The combined results are presented. Results: IOP elevations ≥ 10 mmHg occured in 1% (1/122) of the patients who received brimonidine before and after ALT; in 2% (2/119) of those receiving brimonidine before and vehicle after; in 1% (1/114) of those receiving vehicle before and brimonidine after; and in 23% (27/116) of those receiving vehicle before and after (P <.001). Conclusion: The brimonidine regimens were generally effective and well-tolerated ocularly and systemically.

UR - http://www.scopus.com/inward/record.url?scp=0028805185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028805185&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 404

EP - 409

JO - Ophthalmic Surgery Lasers and Imaging Retina

JF - Ophthalmic Surgery Lasers and Imaging Retina

SN - 2325-8160

IS - 5

ER -