Effect of Beta-Blocker Therapy on Rehospitalization Rates in Women Versus Men With Heart Failure and Preserved Ejection Fraction

S. Morteza Farasat, Dennis T. Bolger, Veena Shetty, Elizabeth Menachery, Gary Gerstenblith, Edward K Kasper, Samer S. Najjar

Research output: Contribution to journalArticle

Abstract

Beta blockers are empirically used in many patients with heart failure (HF) and preserved ejection fraction (HFpEF) because they allow more time for diastolic filling and because they improve outcomes in patients with systolic HF. However, recent data suggest that impaired chronotropic and vasodilator responses to exercise, which can worsen with β blockade, may play a key role in the pathophysiology of HFpEF. We prospectively examined the association between β-blocker therapy after hospitalization for decompensated HF and HF rehospitalization at 6 months in 66 consecutive patients with HFpEF (71 ± 13 years old, 68% women, 42% Black). Subjects were stratified based on receiving (BB+; 15 men, 28 women) or not receiving (BB-) β-blockers at hospital discharge. In men, HF rehospitalization occurred less frequently in the BB+ than in the BB- group, albeit nonsignificantly (20% vs 50%, p = 0.29). In women, HF rehospitalization occurred more frequently in the BB+ than in the BB- group (75% vs 18%, p

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalThe American Journal of Cardiology
Volume105
Issue number2
DOIs
StatePublished - Jan 15 2010

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Heart Failure
Systolic Heart Failure
Therapeutics
Vasodilator Agents
Hospitalization
Exercise

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of Beta-Blocker Therapy on Rehospitalization Rates in Women Versus Men With Heart Failure and Preserved Ejection Fraction. / Farasat, S. Morteza; Bolger, Dennis T.; Shetty, Veena; Menachery, Elizabeth; Gerstenblith, Gary; Kasper, Edward K; Najjar, Samer S.

In: The American Journal of Cardiology, Vol. 105, No. 2, 15.01.2010, p. 229-234.

Research output: Contribution to journalArticle

Farasat, S. Morteza ; Bolger, Dennis T. ; Shetty, Veena ; Menachery, Elizabeth ; Gerstenblith, Gary ; Kasper, Edward K ; Najjar, Samer S. / Effect of Beta-Blocker Therapy on Rehospitalization Rates in Women Versus Men With Heart Failure and Preserved Ejection Fraction. In: The American Journal of Cardiology. 2010 ; Vol. 105, No. 2. pp. 229-234.
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