Effect of antiretroviral therapy on plasma concentrations of chloroquine and desethyl-chloroquine

Matthew M. Ippolito, Jeffrey M. Jacobson, Michael M. Lederman, Markus Winterberg, Joel Tarning, Theresa A. Shapiro, Charles Flexner

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.

Original languageEnglish (US)
Pages (from-to)1617-1620
Number of pages4
JournalClinical Infectious Diseases
Volume67
Issue number10
DOIs
StatePublished - Oct 30 2018

Keywords

  • antiretroviral therapy
  • chloroquine
  • drug-drug interaction

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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