Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus

S. Chiba, R. Hashimoto, S. Hattori, M. Yohda, B. Lipska, D. R. Weinberger, H. Kunugi

Research output: Contribution to journalArticle

Abstract

Altered expression of Disrupted-In-Schizophrenia-1 (DISC1) and dysbindin (DTNBP1), susceptibility genes for schizophrenia, in schizophrenic brain has been reported; however, the possible effect of antipsychotics on the expression levels of these genes has not yet been studied. We measured the mRNA expression levels of these genes in frontal cortex and hippocampus of mice chronically treated with typical and atypical antipsychotics by a real-time quantitative RT-PCR method. We found that atypical antipsychotics, olanzapine and risperidone, in a clinically relevant dose increased DISC1 expression levels in frontal cortex, while a typical antipsychotic, haloperidol, did not. No significant effect on dysbindin expression levels was observed in either brain region. These data suggest that prior evidence of decreased expression of dysbindin in postmortem brain of schizophrenics is not likely to be a simple artifact of antemortem drug treatment. Our results also suggest a potential role of DISC1 in the therapeutic mechanisms of certain atypical antipsychotics.

Original languageEnglish (US)
Pages (from-to)1337-1346
Number of pages10
JournalJournal of Neural Transmission
Volume113
Issue number9
DOIs
StatePublished - Sep 1 2006
Externally publishedYes

Keywords

  • Antipsychotic
  • DISC1
  • Dysbindin
  • Gene expression
  • Schizophrenia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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