TY - JOUR
T1 - Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity
AU - Siddiqui, Ruqaiyyah
AU - Matin, Abdul
AU - Warhurst, David
AU - Stins, Monique
AU - Khan, Naveed Ahmed
PY - 2007/12
Y1 - 2007/12
N2 - Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.
AB - Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.
UR - http://www.scopus.com/inward/record.url?scp=36749080355&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36749080355&partnerID=8YFLogxK
U2 - 10.1128/AAC.00373-07
DO - 10.1128/AAC.00373-07
M3 - Article
C2 - 17875991
AN - SCOPUS:36749080355
SN - 0066-4804
VL - 51
SP - 4471
EP - 4473
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 12
ER -