Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity

Ruqaiyyah Siddiqui, Abdul Matin, David Warhurst, Monique Stins, Naveed Ahmed Khan

Research output: Contribution to journalArticle

Abstract

Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.

Original languageEnglish (US)
Pages (from-to)4471-4473
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number12
DOIs
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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