Effect of anterior-posterior lesion location on the asymmetrical behavioral and biochemical response to cortical suction ablations in the rat

Godfrey D. Pearlson, Kenneth L. Kubos, Robert G. Robinson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Small cortical suction ablations were produced at one of several stereotaxically located sites along the anterior-posterior axis of the right or left hemisphere in the rat. Analysis of variance showed a highly significant effect of lesion location in the right hemisphere on locomotor activity. The most anterior lesions produced both the most hyperactivity and also the greatest reductions in the concentrations of noripinephrine in the ipsilateral and contralateral cortex and locus coeruleus. These results suggest that the effect of cortical lesions on spontaneous activity may be graded across the right hemisphere and that the anatomy of certain neurotransmitter pathways in the cortex may help to explain both the biochemical and behavioral findings.

    Original languageEnglish (US)
    Pages (from-to)241-250
    Number of pages10
    JournalBrain research
    Volume293
    Issue number2
    DOIs
    StatePublished - Feb 20 1984

    Keywords

    • asymmetrical behavior
    • cortical lesions

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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