Effect of antenatal zinc supplementation on impetigo in infants in Bangladesh

Gary L. Darmstadt, Saskia J.M. Osendarp, Saifuddin Ahmed, Candace Feldman, Joop M.A. Van Raaij, Abdullah H. Baqui, J. G.A.J. Hautvast, George J. Fuchs

Research output: Contribution to journalArticlepeer-review

Abstract

We sought to determine the effects of maternal zinc supplementation on skin infections among infants in poor urban areas of Dhaka, Bangladesh. A double-blind, placebo-controlled, randomized trial was conducted among 199 and 221 Bangladeshi infants whose mothers were administered 30 mg daily of zinc or placebo, respectively. The mothers received zinc supplementation from 12-16 weeks' gestation until delivery, and the infants were followed up until 6 months of age. Among the infants of mothers who received zinc supplementation during the antenatal period, 10.6% had at least 1 episode of impetigo compared with 19.6% of the infants of mothers in the placebo group (P = 0.01). Infants in the treatment group had a 54% reduction in incidence rate of episodes of impetigo when compared with infants in the placebo group (P = 0.01). The effect of zinc supplementation was more pronounced among male infants (64% reduction) and intrauterine growth restricted and low birth weight infants (73% reduction) and among infants of mothers with increased parity (60% reduction) or decreased socioeconomic status (71% reduction).

Original languageEnglish (US)
Pages (from-to)407-409
Number of pages3
JournalPediatric Infectious Disease Journal
Volume31
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • acute lower respiratory infection
  • impetigo
  • infant
  • morbidity
  • photograph
  • pneumonia
  • skin infection
  • supplementation
  • zinc

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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