Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans

Julian F. Thayer, Marcellus M. Merritt, John J. Sollers, Alan B. Zonderman, Michele K. Evans, Sue Yie, Darrell R. Abernethy

Research output: Contribution to journalArticlepeer-review

Abstract

Seventy-nine African-American participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) pilot study were genotyped for the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and had spectral power of their high-frequency (HF) heart rate variability (HRV) determined by fast-Fourier transformation. HF HRV was highest in II, intermediate in ID, and lowest in DD (II vs DD, p <0.043) genotypes, thus making an association of the ACE I/D DD genotype with decreased HF HRV that is consistent with the hypothesis that the DD genotype confers susceptibility to increased cardiovascular risk. The urban African-American population we studied had a particularly high cardiovascular risk, and these findings suggest that ACE I/D genotypes may modify that risk.

Original languageEnglish (US)
Pages (from-to)1487-1490
Number of pages4
JournalAmerican Journal of Cardiology
Volume92
Issue number12
DOIs
StatePublished - Dec 15 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans'. Together they form a unique fingerprint.

Cite this