TY - JOUR
T1 - Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans
AU - Thayer, Julian F.
AU - Merritt, Marcellus M.
AU - Sollers, John J.
AU - Zonderman, Alan B.
AU - Evans, Michele K.
AU - Yie, Sue
AU - Abernethy, Darrell R.
PY - 2003/12/15
Y1 - 2003/12/15
N2 - Seventy-nine African-American participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) pilot study were genotyped for the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and had spectral power of their high-frequency (HF) heart rate variability (HRV) determined by fast-Fourier transformation. HF HRV was highest in II, intermediate in ID, and lowest in DD (II vs DD, p <0.043) genotypes, thus making an association of the ACE I/D DD genotype with decreased HF HRV that is consistent with the hypothesis that the DD genotype confers susceptibility to increased cardiovascular risk. The urban African-American population we studied had a particularly high cardiovascular risk, and these findings suggest that ACE I/D genotypes may modify that risk.
AB - Seventy-nine African-American participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) pilot study were genotyped for the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and had spectral power of their high-frequency (HF) heart rate variability (HRV) determined by fast-Fourier transformation. HF HRV was highest in II, intermediate in ID, and lowest in DD (II vs DD, p <0.043) genotypes, thus making an association of the ACE I/D DD genotype with decreased HF HRV that is consistent with the hypothesis that the DD genotype confers susceptibility to increased cardiovascular risk. The urban African-American population we studied had a particularly high cardiovascular risk, and these findings suggest that ACE I/D genotypes may modify that risk.
UR - http://www.scopus.com/inward/record.url?scp=0346366834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0346366834&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2003.08.069
DO - 10.1016/j.amjcard.2003.08.069
M3 - Article
C2 - 14675596
AN - SCOPUS:0346366834
SN - 0002-9149
VL - 92
SP - 1487
EP - 1490
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 12
ER -